2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol

Base Information

Chemical Name:2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol
CAS No.:1256918-39-4
Molecular Formula:C₂₉H₂₈Cl₂F₂N₂O₄S
Molecular Weight:609.521
Hs Code.:

Synonyms:2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol

Suppliers and Price of 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol

There total 10 articles about 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (2-fluoro-6-(methylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

: 2-(1-(4-bromo-2-fluorophenyl)-2-(2-(2,6-dichlorophenyl)propan-2-yl)-1H-imidazol-4-yl)propan-2-ol

: 1256918-39-4
2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol

Guidance literature:: (2-fluoro-6-(methylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol; 2-(1-(4-bromo-2-fluorophenyl)-2-(2-(2,6-dichlorophenyl)propan-2-yl)-1H-imidazol-4-yl)propan-2-ol; With palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; In 2-methyltetrahydrofuran; at 23 ℃; for 0.25h; Inert atmosphere; Large scale;

With potassium hydroxide; In 2-methyltetrahydrofuran; water; at 20 - 50 ℃; for 2h; Concentration; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Large scale;

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 1256918-39-4
2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: trimethylaluminum / toluene; o-xylene / 3 h / 100 °C / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran; toluene / 2.33 h / 55 °C

3.1: trifluoroacetic acid / ethanol / 2.5 h / 95 °C

4.1: tetrahydrofuran; dichloromethane; diethyl ether / 1.75 h / -17 - 0 °C

5.1: bis[2-(diphenylphosphino)phenyl] ether; palladium diacetate / 2-methyltetrahydrofuran / 0.25 h / 23 °C / Inert atmosphere; Large scale

5.2: 2 h / 20 - 50 °C / Inert atmosphere; Large scale

With trimethylaluminum; palladium diacetate; potassium carbonate; trifluoroacetic acid; bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; 2-methyltetrahydrofuran; diethyl ether; ethanol; dichloromethane; o-xylene; toluene; 5.1: |Suzuki Coupling;

Reference yield:

: (4-bromo-2-fluoro-6-(methylthio)phenyl)methanol

: 1256918-39-4
2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3‘-difluoro-4’-(hydroxymethyl)-5'-(methylsulfonyl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-4-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / dimethyl sulfoxide / 3 h / 90 °C / Inert atmosphere

3.1: bis[2-(diphenylphosphino)phenyl] ether; palladium diacetate / 2-methyltetrahydrofuran / 0.25 h / 23 °C / Inert atmosphere; Large scale

3.2: 2 h / 20 - 50 °C / Inert atmosphere; Large scale

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; bis[2-(diphenylphosphino)phenyl] ether; In 2-methyltetrahydrofuran; dichloromethane; dimethyl sulfoxide; 2.1: |Suzuki Coupling / 3.1: |Suzuki Coupling;