diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate

Base Information

Chemical Name:diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate
CAS No.:1301660-78-5
Molecular Formula:C₃₅H₃₄F₇N₃O₆
Molecular Weight:725.66
Hs Code.:

diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate

Synonyms:diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate

Suppliers and Price of diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate

There total 5 articles about diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1301660-58-1
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-propenoate

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 1301660-78-5
diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate

Guidance literature:: 2-acetylaminomalonic acid diethyl ester; With sodium ethanolate; In ethanol; dimethyl sulfoxide; at 20 ℃; for 0.5h;

ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-propenoate; In ethanol; dimethyl sulfoxide; at 110 ℃; for 18h;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-78-5
diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 0.5 h / 20 °C

4.2: 18 h / 110 °C

With osmium(VIII) oxide; water; sodium ethanolate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1263187-14-9
3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-acrylic acid ethyl ester

: 1301660-78-5
diethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5-oxo-2,2-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 140 °C / Microwave irradiation

2.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 18 h / 110 °C

With sodium ethanolate; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; 1.1: Suzuki Coupling;