N-<3(RS)--1-oxo-2-benzylpropyl>glycine methyl ester

Base Information

• Chemical Name: N-<3(RS)--1-oxo-2-benzylpropyl>glycine methyl ester
• CAS No.: 96866-17-0
• Molecular Formula: C₂₁H₂₄N₂O₅
• Molecular Weight: 384.432

Synonyms:N-<3(RS)--1-oxo-2-benzylpropyl>glycine methyl ester

Chemical Property of N-<3(RS)--1-oxo-2-benzylpropyl>glycine methyl ester

Chemical Property:

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Technology Process of N-<3(RS)--1-oxo-2-benzylpropyl>glycine methyl ester

There total 4 articles about N-<3(RS)--1-oxo-2-benzylpropyl>glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 3(RS)--2-benzylpropanoic acid (96866-15-8) → N-<3(RS)--1-oxo-2-benzylpropyl>glycine methyl ester (96866-17-0)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; Ambient temperature;

DOI:10.1021/jm00147a007

Reference yield:

2-Benzyl-2-propenoic acid (5669-19-2) → N-<3(RS)--1-oxo-2-benzylpropyl>glycine methyl ester (96866-17-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / ethanol / 168 h / Heating

2: 98 percent / acetic anhydride / 3 h / 0 °C

3: 87 percent / Et₃N, 1-hydroxybenzotriazol (HOBT), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

With acetic anhydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; chloroform;

DOI:10.1021/jm00147a007

Reference yield:

N-benzyloxyamine (622-33-3) → N-<3(RS)--1-oxo-2-benzylpropyl>glycine methyl ester (96866-17-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / ethanol / 168 h / Heating

2: 98 percent / acetic anhydride / 3 h / 0 °C

3: 87 percent / Et₃N, 1-hydroxybenzotriazol (HOBT), DCC / tetrahydrofuran; CHCl₃ / Ambient temperature

With acetic anhydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; chloroform;

DOI:10.1021/jm00147a007

upstream raw materials:

glycine ethyl ester hydrochloride

3(RS)--2-benzylpropanoic acid

N-benzyloxyamine

2-Benzyl-2-propenoic acid

Downstream raw materials:

N-[3(RS)-(N-formyl-N-hydroxyamino)-1-oxo-2-benzylpropyl]glycine methyl ester

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