(3S,4R)-1-(4-methoxybenzyl)-4-<(phenylthiocarbonyl)methyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Base Information

Chemical Name:(3S,4R)-1-(4-methoxybenzyl)-4-<(phenylthiocarbonyl)methyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone
CAS No.:90629-24-6
Molecular Formula:C₂₉H₂₈N₂O₈S
Molecular Weight:564.616
Hs Code.:

Synonyms:(3S,4R)-1-(4-methoxybenzyl)-4-<(phenylthiocarbonyl)methyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Suppliers and Price of (3S,4R)-1-(4-methoxybenzyl)-4-<(phenylthiocarbonyl)methyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4R)-1-(4-methoxybenzyl)-4-<(phenylthiocarbonyl)methyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4R)-1-(4-methoxybenzyl)-4-<(phenylthiocarbonyl)methyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

There total 10 articles about (3S,4R)-1-(4-methoxybenzyl)-4-<(phenylthiocarbonyl)methyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

: 80675-54-3
((1-(phenylthio)vinyl)oxy)trimethylsilane

: (3S,4R)-4-acetoxy-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-1-(4-methoxybenzyl)-2-azetidinone

: 90629-24-6
(3S,4R)-1-(4-methoxybenzyl)-4-<(phenylthiocarbonyl)methyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; Ambient temperature;
DOI:10.1246/bcsj.58.3264

Reference yield: 32.0%

: 98729-75-0
Carbonic acid (R)-1-[(3S,4S)-1-(4-methoxy-benzyl)-2-oxo-4-phenylsulfanylethynyl-azetidin-3-yl]-ethyl ester 4-nitro-benzyl ester

: 90629-24-6
(3S,4R)-1-(4-methoxybenzyl)-4-<(phenylthiocarbonyl)methyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1016/S0040-4039(00)88946-7

Reference yield:

: 98076-56-3
[(4-Methoxy-benzyl)-amino]-acetic Acid Tert-butyl Ester

: 90629-24-6
(3S,4R)-1-(4-methoxybenzyl)-4-<(phenylthiocarbonyl)methyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 7 steps

1: 71.5 percent / N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 0.5 h / 20 - 30 °C

2: n-BuLi, hexamethyldisilazane / tetrahydrofuran; hexane / 1) 1) 2 to 3 deg C, 2) 20 to 23 deg C, 30 min

3: 5percent NaHCO₃ / ethyl acetate

4: trifluoroacetic acid / 3 h / 0 °C

5: 51.3 percent / dimethylformamide; acetic acid / 0.25 h / 50 - 55 °C

6: 74 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 1 h

7: 94.9 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / Ambient temperature

With dmap; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.58.3264