(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-2-((E)-3-(4-tolyl)acrylamido)pentanamide

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Chemical Name:(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-2-((E)-3-(4-tolyl)acrylamido)pentanamide
CAS No.:1392506-13-6
Molecular Formula:C₃₅H₃₇ClN₄O₃
Molecular Weight:597.157
Hs Code.:

Synonyms:(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-2-((E)-3-(4-tolyl)acrylamido)pentanamide

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Chemical Property of (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-2-((E)-3-(4-tolyl)acrylamido)pentanamide

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Technology Process of (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-2-((E)-3-(4-tolyl)acrylamido)pentanamide

There total 4 articles about (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-2-((E)-3-(4-tolyl)acrylamido)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1866-39-3,940-61-4
trans-p-methylcinnamic acid

: 1392506-10-3
(R)-2-amino-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-pentanamide

: 1392506-13-6
(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-2-((E)-3-(4-tolyl)acrylamido)pentanamide

Guidance literature:: trans-p-methylcinnamic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.333333h; Reflux;

(R)-2-amino-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-pentanamide; In dichloromethane; for 72h;
DOI:10.1016/j.ejmech.2012.05.022

Reference yield:

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1392506-13-6
(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-2-((E)-3-(4-tolyl)acrylamido)pentanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonia; phenol / 2 h / 150 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

3.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

3.2: pH 12

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

4.2: 24 h / 0 - 20 °C

5.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

5.2: pH 12

6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / Reflux

6.2: 72 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; phenol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.05.022

Reference yield:

: 1392506-09-0
tert-butyl ((R)-1-(((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate

: 1392506-13-6
(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-2-((E)-3-(4-tolyl)acrylamido)pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

1.2: pH 12

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / Reflux

2.2: 72 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2012.05.022