(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one

Base Information

Chemical Name:(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one
CAS No.:1188335-29-6
Molecular Formula:C₂₈H₃₄FN₅O₇Si
Molecular Weight:599.691
Hs Code.:

(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one

Synonyms:(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one

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Chemical Property of (R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one

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Technology Process of (R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one

There total 5 articles about (R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 627541-90-6
(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-[3-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-oxazolidin-2-one

: 1188329-26-1
(6S)-6-[(6-bromo-3-pyridinyl)methoxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

: 1188335-29-6
(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 80 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 1188330-70-2
(R)-3-(4-bromo-3-fluoro-phenyl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-oxazolidin-2-one

: 1188335-29-6
(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 2.5 h / 80 °C / Inert atmosphere

With potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1188335-29-6
(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-{3-fluoro-4-[5-((S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yloxymethyl)-pyridin-2-yl]-phenyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / tetrahydrofuran

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 2.5 h / 80 °C / Inert atmosphere

With 1H-imidazole; potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;