4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid 2,5-dioxopyrrolidin-1-yl ester

Base Information

Chemical Name:4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid 2,5-dioxopyrrolidin-1-yl ester
CAS No.:945528-84-7
Molecular Formula:C₅₁H₈₁N₅O₁₅
Molecular Weight:1004.23
Hs Code.:

4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid 2,5-dioxopyrrolidin-1-yl ester

Synonyms:4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid 2,5-dioxopyrrolidin-1-yl ester

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Chemical Property of 4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid 2,5-dioxopyrrolidin-1-yl ester

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Technology Process of 4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid 2,5-dioxopyrrolidin-1-yl ester

There total 3 articles about 4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid 2,5-dioxopyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 945528-82-5
4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 945528-84-7
4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid 2,5-dioxopyrrolidin-1-yl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 18h;
DOI:10.1021/jm061324m

Reference yield:

: 945528-80-3
{[2-(bis-tert-butoxycarbonylmethylamino)-3-(4-nitrophenyl)propyl]-[2-(bis-tert-butoxycarbonylmethylamino)propyl]amino}acetic acid tert-butyl ester

: 945528-84-7
4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid 2,5-dioxopyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / Pd/C / ethanol

2: 82 percent / ethyl acetate / 18 h / 20 °C

3: 83 percent / EDCI / acetonitrile / 18 h / 20 °C

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; ethyl acetate; acetonitrile;
DOI:10.1021/jm061324m

Reference yield:

: 945528-81-4
{[3-(4-aminophenyl)-2-(bis-tert-butoxycarbonylmethylamino)propyl]-[2-(bis-tert-butoxycarbonylmethylamino)propyl]amino}acetic acid tert-butyl ester

: 945528-84-7
4-[4-(2-(bis-tert-butoxycarbonylmethylamino)-3-{[2-(bis-tert-butoxycarbonylmethylamino)propyl]-tert-butoxycarbonylmethylamino}propyl)phenylcarbamoyl]butyric acid 2,5-dioxopyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / ethyl acetate / 18 h / 20 °C

2: 83 percent / EDCI / acetonitrile / 18 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; acetonitrile;
DOI:10.1021/jm061324m