4-methyl-N-p-tolyl-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

Base Information

• Chemical Name: 4-methyl-N-p-tolyl-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline
• CAS No.: 1310371-02-8
• Molecular Formula: C₄₁H₃₀F₃N₃S
• Molecular Weight: 653.771
• Mol file: 1310371-02-8.mol

Synonyms:4-methyl-N-p-tolyl-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

Chemical Property of 4-methyl-N-p-tolyl-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-p-tolyl-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline

There total 2 articles about 4-methyl-N-p-tolyl-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.4%

4-methyl-N-(4-methylphenyl)-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amine (528610-00-6) + 4-(5-bromothiophen-2-yl)-6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridine (1310370-99-0) → 4-methyl-N-p-tolyl-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline (1310371-02-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 65 ℃; for 14h; Inert atmosphere;

DOI:10.1021/ic1025679

Reference yield:

1-[2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl]pyridinium iodide (1310371-07-3) → 4-methyl-N-p-tolyl-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline (1310371-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / N,N-dimethyl-formamide / 14 h / 120 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 14 h / 65 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1: Kr?hnke condensation / 2: Suzuki reaction;

DOI:10.1021/ic1025679

Reference yield: 70.4%

trichloro(trimethyl-4,4',4''-tricarboxylate-2,2':6',2''-terpyridine)ruthenium (330680-47-2) + 4-methyl-N-p-tolyl-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline (1310371-02-8) + water (7732-18-5) + silver nitrate → (4-methyl-N-p-tolyl-N-[4-[5-[6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridin-4-yl]thiophen-2-yl]phenyl]aniline(-1H))(trimethyl-4,4',4''-tricarboxylate-2,2':6',2''-terpyridine)ruthenium(II) nitrate dihydrate

Guidance literature:

With N-ethylmorpholine; In tetrahydrofuran; methanol; water; Ru complex and N-ethylmorpholine added to MeOH-H2O-THF soln. of ligand; refluxed for 16 h; AgNO3 added; refluxed for 1.5 h; cooled; preabsorbed on silica; solvent removed in vac.; purified by column chromy. (silica, CH2Cl2-MeOH 9:1); elem. anal.;

DOI:10.1021/ic1025679

upstream raw materials:

4-methyl-N-(4-methylphenyl)-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amine

4-(5-bromothiophen-2-yl)-6-[3-(trifluoromethyl)phenyl]-2,2'-bipyridine

1-[2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl]pyridinium iodide