3-(N-Acetyl-N-methylamino)pyrrolidine

Base Information

• Chemical Name: 3-(N-Acetyl-N-methylamino)pyrrolidine
• CAS No.: 79286-87-6
• Molecular Formula: C7H14N2O
• Molecular Weight: 142.201
• Hs Code.: 2933990090
• Mol file: 79286-87-6.mol

Synonyms:3-(N-Acetyl-N-methylamino)pyrrolidine;3-(N-Methylacetamido)pyrrolidine;N-Methyl-N-3-pyrrolidinylacetamide;3-(Acetylmethylamino)pyrrolidine;N-Methyl-N-(pyrrolidin-3-yl)acetamide;AC1Q3X88;MolPort-001-794-457;A80222;

Chemical Property of 3-(N-Acetyl-N-methylamino)pyrrolidine

Chemical Property:

• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.492
• Boiling Point: 250.235 °C at 760 mmHg
• Flash Point: 105.139 °C
• PSA: 32.34000
• Density: 1.031 g/cm³
• LogP: 0.15540

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-(N-Acetyl-N-methylamino)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(N-Acetyl-N-methylamino)pyrrolidine

There total 2 articles about 3-(N-Acetyl-N-methylamino)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(tert-butyloxycarbonyl)-3-(N-methylacetamido)pyrrolidine (1160938-28-2,438585-60-5) → (RS)-3-(acetyl-methyl-amino)-pyrrolidine (79286-87-6,550370-77-9,550370-81-5)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 20 ℃; for 1h;

Reference yield:

1-benzyl-3-(methylamino)pyrrolidine (96568-35-3) → 3-(N-acetyl-N-methylamino)-1-benzylpyrrolidine + (RS)-3-(acetyl-methyl-amino)-pyrrolidine (79286-87-6,550370-77-9,550370-81-5)

Guidance literature:

With acetic anhydride; In palladium-carbon;

Reference yield: 100.0%

6-methoxy-1,5-naphthyridin-4-yl trifluoromethanesulfonate (394223-86-0) + (RS)-3-(acetyl-methyl-amino)-pyrrolidine (79286-87-6,550370-77-9,550370-81-5) → N-[1-(6-methoxy-[1,5]naphthyridin-4-yl)-pyrrolidin-3-yl]-N-methyl-acetamide (876345-68-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 50 ℃;

upstream raw materials:

1-benzyl-3-(methylamino)pyrrolidine

1-(tert-butyloxycarbonyl)-3-(N-methylacetamido)pyrrolidine

Downstream raw materials:

7-[3-(N-methylacetamido)-1-pyrrolidinyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

7-[3-(Acetyl-methyl-amino)-pyrrolidin-1-yl]-6-fluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

ethyl 7-[3-(N-acetyl-N-methylamino)-1-pyrrolidinyl]-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

6-Fluoro-1-(4-fluoro-phenyl)-7-(3-methylamino-pyrrolidin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid; hydrochloride

Refernces

• 1、 -. "Antibacterial 7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives". . . Retrieved 2008/06/13.