[(12S)-3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2,4,6-tetraen-12-yl]methanol

Base Information

• Chemical Name: [(12S)-3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2,4,6-tetraen-12-yl]methanol
• CAS No.: 1447952-70-6
• Molecular Formula: C₂₁H₃₀N₄O₂S
• Molecular Weight: 402.561

Synonyms:[(12S)-3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2,4,6-tetraen-12-yl]methanol

Chemical Property of [(12S)-3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2,4,6-tetraen-12-yl]methanol

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Technology Process of [(12S)-3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2,4,6-tetraen-12-yl]methanol

There total 2 articles about [(12S)-3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2,4,6-tetraen-12-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

(1r,4r)-4-(morpholin-4-yl)cyclohexan-1-amine dihydrochloride (412356-24-2,1683576-26-2) + C11H13N3OS → [(12S)-3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1(9),2,4,6-tetraen-12-yl]methanol (1447952-70-6)

Guidance literature:

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃; for 60h; Inert atmosphere;

Reference yield:

tert-butyl N-[4-(morpholin-4-yl)cyclohexyl]carbamate (558442-96-9) → [(12S)-3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6-diazatricyclo[7.4.0.0[2,7]]trideca-1(9),2,4,6-tetraen-12-yl]methanol (1447952-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; water / 0 - 20 °C

2: potassium carbonate; N-ethyl-N,N-diisopropylamine / acetonitrile / 60 h / 80 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; water; acetonitrile;

upstream raw materials:

(1r,4r)-4-(morpholin-4-yl)cyclohexan-1-amine dihydrochloride

tert-butyl N-[4-(morpholin-4-yl)cyclohexyl]carbamate

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