tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate

Base Information

• Chemical Name: tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate
• CAS No.: 558442-96-9
• Molecular Formula: C15H28N2O3
• Molecular Weight: 284.399
• Mol file: 558442-96-9.mol

Synonyms:tert-butyl trans-4-(4-morpholinyl)cyclohexylcarbamate;tert-butyl(1r,4r)-4-morpholinocyclohexylcarbamate;

Chemical Property of tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate

Chemical Property:

• Boiling Point: 396.3±37.0 °C(Predicted)
• PKA: 12.50±0.40(Predicted)
• PSA: 50.80000
• Density: 1.07±0.1 g/cm3(Predicted)
• LogP: 2.48330
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl((1r,4r)-4-morpholinocyclohexyl)-carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate

There total 5 articles about tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1,1'-oxybis(2-bromo-ethane) (5414-19-7) + trans-N-Boc-1,4-cyclohexanediamine (177906-48-8) → tert-butyl N-[4-(morpholin-4-yl)cyclohexyl]carbamate (558442-96-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 6h;

Reference yield:

3-oxa-1,5-dichloropentane (111-44-4) + trans-N-Boc-1,4-cyclohexanediamine (177906-48-8) → tert-butyl N-[4-(morpholin-4-yl)cyclohexyl]carbamate (558442-96-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield:

1,1'-oxybis(2-bromo-ethane) (5414-19-7) + tert-butyl (4-aminocyclohexyl)carbamate (195314-59-1) → tert-butyl N-[4-(morpholin-4-yl)cyclohexyl]carbamate (558442-96-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 16h;

upstream raw materials:

1,1'-oxybis(2-bromo-ethane)

trans-N-Boc-1,4-cyclohexanediamine

tert-butyl (4-aminocyclohexyl)carbamate

3-oxa-1,5-dichloropentane

Downstream raw materials:

(1r,4r)-4-(morpholin-4-yl)cyclohexan-1-amine

2-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraene-12-sulfonyl)ethan-1-ol

12-(ethanesulfonyl)-N-[4-(morpholin-4-yl)cyclohexyl]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraen-3-amine

1-(3-[[4-(morpholin-4-yl)cyclohexyl]amino]-8-thia-4,6,12-triazatricyclo[7.4.0.0[2,7]]trideca-1⁽⁹⁾,2⁽⁷⁾,3,5-tetraen-12-yl)ethan-1-one

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