1-(5-(7-acetamido-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea

Base Information

Chemical Name:1-(5-(7-acetamido-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea
CAS No.:1442473-11-1
Molecular Formula:C₂₅H₂₁BrFN₅O₃
Molecular Weight:538.376
Hs Code.:

Synonyms:1-(5-(7-acetamido-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea

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Chemical Property of 1-(5-(7-acetamido-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea

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Technology Process of 1-(5-(7-acetamido-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea

There total 12 articles about 1-(5-(7-acetamido-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1442473-09-7
1-(5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3- phenylurea

: 108-24-7
acetic anhydride

: 1442473-11-1
1-(5-(7-acetamido-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea

Guidance literature:: at 110 ℃; for 4h;

Reference yield:

: 1442470-72-5
7-(4-methoxybenzylamino)-3-(5-amino-2-bromo-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

: 1442473-11-1
1-(5-(7-acetamido-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / trifluoroacetic acid; ethyl acetate / 48 h / 50 - 60 °C

2: triethylamine / dichloromethane / 72 h / 20 °C

3: 4 h / 110 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; ethyl acetate; trifluoroacetic acid;

Reference yield:

: 61150-59-2
2-(2-bromo-4-fluorophenyl)acetic acid

: 1442473-11-1
1-(5-(7-acetamido-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-bromo-2-fluorophenyl)-3-phenylurea

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid / ethyl acetate / 0.25 h / -15 - 5 °C

2: sulfuric acid / 85 °C

3: iron; ammonium chloride / ethanol / 1 h / 55 °C

4: potassium fluoride; aluminum oxide / N,N-dimethyl acetamide / 2 h / Sonication

5: 140 °C

6: trifluoroacetic acid / trifluoroacetic acid; ethyl acetate / 48 h / 50 - 60 °C

7: triethylamine / dichloromethane / 72 h / 20 °C

8: 4 h / 110 °C

With aluminum oxide; potassium fluoride; sulfuric acid; nitric acid; iron; ammonium chloride; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl acetamide; ethyl acetate; trifluoroacetic acid;