2-(3-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-(3-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 786654-97-5
• Molecular Formula: C12H10 Br N O2 S
• Molecular Weight: 312.187
• Hs Code.: 2934100090
• Mol file: 786654-97-5.mol

Synonyms:Ethyl2-(3-bromophenyl)-1,3-thiazole-4-carboxylate

Chemical Property of 2-(3-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 4.2E-07mmHg at 25°C
• Refractive Index: 1.602
• Boiling Point: 415.2°C at 760 mmHg
• Flash Point: 204.9°C
• PSA: 67.43000
• Density: 1.5g/cm³
• LogP: 3.74930
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(3-Bromo-phenyl)-thiazole-4-carboxylicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

There total 4 articles about 2-(3-BROMO-PHENYL)-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-bromothiobenzamide (2227-62-5) + ethyl Bromopyruvate (70-23-5) → ethyl 2-(3-bromophenyl)-1,3-thiazole-4-carboxylate (786654-97-5)

Guidance literature:

In ethanol; for 16h; Heating / reflux;

Reference yield: 68.0%

ethyl 2-bromothiazole-4-carboxylate (100367-77-9) + (3-bromophenyl)boronic acid (89598-96-9) → ethyl 2-(3-bromophenyl)-1,3-thiazole-4-carboxylate (786654-97-5)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; water; at 90 ℃; Microwave irradiation; Sealed tube;

Reference yield: 56.0%

m-bromobenzoic aldehyde (3132-99-8) + L-cysteine ethyl ester hydrochloride (868-59-7) → ethyl 2-(3-bromophenyl)-1,3-thiazole-4-carboxylate (786654-97-5)

Guidance literature:

With tert.-butylhydroperoxide; iodine; potassium carbonate; In 1,4-dioxane; at 70 ℃; for 12h; Schlenk technique; Molecular sieve; Inert atmosphere;

DOI:10.1039/c8ob02826e

upstream raw materials:

3-bromothiobenzamide

ethyl Bromopyruvate

ethyl 2-bromothiazole-4-carboxylate

(3-bromophenyl)boronic acid

Downstream raw materials:

[3-(bromo-phenyl)-thiazol-4-yl]-methanol

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