(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate

Base Information

Chemical Name:(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate
CAS No.:1340546-27-1
Molecular Formula:C₇H₆O₂*C₁₇H₂₁NO₃
Molecular Weight:409.482
Hs Code.:

Synonyms:(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate

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Chemical Property of (2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate

Chemical Property:

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Technology Process of (2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate

There total 11 articles about (2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4407-36-7
(2E)-3-phenyl-2-propen-1-ol

: 1340546-27-1
(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 3-chloro-benzenecarboperoxoic acid

2: chloro-trimethyl-silane / ethyl acetate / -20 °C

3: isopropyl alcohol

4: hydrogenchloride / water; ethyl acetate

5: sodium hydroxide / toluene

6: methanol; ammonia / isopropyl alcohol

7: (-)-camphanic acid; sodium hydroxide / water; toluene

With hydrogenchloride; methanol; chloro-trimethyl-silane; ammonia; (-)-camphanic acid; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In water; ethyl acetate; isopropyl alcohol; toluene;
DOI:10.1039/c1gc15921f

Reference yield:

: 93853-04-4,98769-75-6
(2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate

: 1340546-27-1
(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; toluene / 1.5 h / 55 °C / Large scale reaction

2: diethylamine; trifluoroacetic acid / n-heptane; isopropyl alcohol / 0.2 h / 45 °C / Resolution of racemate; Large scale reaction

3: toluene / 32 h / 20 - 70 °C / Large scale reaction

With diethylamine; trifluoroacetic acid; sodium hydroxide; In n-heptane; water; isopropyl alcohol; toluene;
DOI:10.1021/op200181f

Reference yield:

: 93851-63-9,93851-64-0,93853-03-3,98769-74-5,98769-76-7,98819-73-9
(2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane

: 1340546-27-1
(2S,3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylamine benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamine; trifluoroacetic acid / n-heptane; isopropyl alcohol / 0.2 h / 45 °C / Resolution of racemate; Large scale reaction

2: toluene / 32 h / 20 - 70 °C / Large scale reaction

With diethylamine; trifluoroacetic acid; In n-heptane; isopropyl alcohol; toluene;
DOI:10.1021/op200181f