(2RS,3RS)-1-AMINO-3-(2-ETHOXYPHENOXY)-2-HYDROXY-3-PHENYLPROPANE, METHANESULFONATE SALT

Base Information

Chemical Name:(2RS,3RS)-1-AMINO-3-(2-ETHOXYPHENOXY)-2-HYDROXY-3-PHENYLPROPANE, METHANESULFONATE SALT
CAS No.:93853-04-4
Molecular Formula:CH₄O₃S*C₁₇H₂₁NO₃
Molecular Weight:383.466
Hs Code.:
Mol file:93853-04-4.mol

Synonyms:Reboxetine Desmethylene Mesylate;α-(AMinoMethyl)-β-(2-ethoxyphenoxy)benzeneethanol Methanesulfonate;(2RS,3RS)-1-AMINO-3-(2-ETHOXYPHENOXY)-2-HYDROXY-3-PHENYLPROPANE, METHANESULFONATE SALT

Suppliers and Price of (2RS,3RS)-1-AMINO-3-(2-ETHOXYPHENOXY)-2-HYDROXY-3-PHENYLPROPANE, METHANESULFONATE SALT

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Medical Isotopes, Inc.
(2RS,3RS)-1-Amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropaneMethanesulfonateSalt
10 mg
$ 820.00

Medical Isotopes, Inc.
(2RS,3RS)-1-Amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropaneMethanesulfonateSalt
50 mg
$ 1560.00

Biosynth Carbosynth
(2RS,3RS)-1-Amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate salt
100 mg
$ 1202.00

Biosynth Carbosynth
(2RS,3RS)-1-Amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate salt
50 mg
$ 660.50

Biosynth Carbosynth
(2RS,3RS)-1-Amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate salt
10 mg
$ 199.90

Biosynth Carbosynth
(2RS,3RS)-1-Amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate salt
5 mg
$ 109.90

Biosynth Carbosynth
(2RS,3RS)-1-Amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate salt
25 mg
$ 363.50

American Custom Chemicals Corporation
(2RS,3RS)-1-AMINO-3-(2-ETHOXYPHENOXY)-2-HYDROXY-3-PHENYLPROPANE METHANESULFONATE 95.00%
5MG
$ 496.35

American Custom Chemicals Corporation
(2RS,3RS)-1-AMINO-3-(2-ETHOXYPHENOXY)-2-HYDROXY-3-PHENYLPROPANE METHANESULFONATE 95.00%
1MG
$ 269.85

AK Scientific
(2RS,3RS)-1-Amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropaneMethanesulfonateSalt
25mg
$ 540.00

Total 7 raw suppliers

Chemical Property of (2RS,3RS)-1-AMINO-3-(2-ETHOXYPHENOXY)-2-HYDROXY-3-PHENYLPROPANE, METHANESULFONATE SALT

Chemical Property:

Melting Point:118-120°C
PSA：127.46000
LogP:3.81010

Purity/Quality:

99% ^*data from raw suppliers

(2RS,3RS)-1-Amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropaneMethanesulfonateSalt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses An intermediate in the synthesis of Reboxetine (R142000).

Technology Process of (2RS,3RS)-1-AMINO-3-(2-ETHOXYPHENOXY)-2-HYDROXY-3-PHENYLPROPANE, METHANESULFONATE SALT

There total 17 articles about (2RS,3RS)-1-AMINO-3-(2-ETHOXYPHENOXY)-2-HYDROXY-3-PHENYLPROPANE, METHANESULFONATE SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4407-36-7
(2E)-3-phenyl-2-propen-1-ol

: 93853-04-4,98769-75-6
(2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: MCPBA / CH₂Cl₂ / 0 deg C, 1.5 h, then RT, 24 h

2: 1.) NaOH / 1.) H₂O, 70 deg C; 2.) H₂O, 70 deg C, 2.5 h

3: 61 percent / pyridine / 2 h / -10 °C

4: 84 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 5 °C

5: 2N NaOH / dioxane / 4 h / Ambient temperature

6: 32percent NH₄OH / methanol / 6 h / sealed flask

7: ethyl acetate / 16 h

With ammonium hydroxide; sodium hydroxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; pyridine; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(01)96541-X

Reference yield:

: 40641-81-4
trans-2,3-epoxy-3-phenylpropan-1-ol

: 93853-04-4,98769-75-6
(2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaOH / 1.) H₂O, 70 deg C; 2.) H₂O, 70 deg C, 2.5 h

2: 61 percent / pyridine / 2 h / -10 °C

3: 84 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 5 °C

4: 2N NaOH / dioxane / 4 h / Ambient temperature

5: 32percent NH₄OH / methanol / 6 h / sealed flask

6: ethyl acetate / 16 h

With ammonium hydroxide; sodium hydroxide; triethylamine; In 1,4-dioxane; pyridine; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(01)96541-X

Reference yield:

: 98769-72-3,98819-72-8
(2RS,3RS)-3-(2-ethoxyphenoxy)-3-phenylpropene-1,2-epoxide

: 93853-04-4,98769-75-6
(2RS,3RS)-1-amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 32percent NH₄OH / methanol / 6 h / sealed flask

2: ethyl acetate / 16 h

With ammonium hydroxide; In methanol; ethyl acetate;
DOI:10.1016/S0040-4020(01)96541-X