5-(tert-butyldimethylsilyloxy)-3-methylene-1-(pentafluorophenyl)pentan-1-ol

Base Information

Chemical Name:5-(tert-butyldimethylsilyloxy)-3-methylene-1-(pentafluorophenyl)pentan-1-ol
CAS No.:1358895-33-6
Molecular Formula:C₁₈H₂₅F₅O₂Si
Molecular Weight:396.473
Hs Code.:

Synonyms:5-(tert-butyldimethylsilyloxy)-3-methylene-1-(pentafluorophenyl)pentan-1-ol

Suppliers and Price of 5-(tert-butyldimethylsilyloxy)-3-methylene-1-(pentafluorophenyl)pentan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(tert-butyldimethylsilyloxy)-3-methylene-1-(pentafluorophenyl)pentan-1-ol

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Technology Process of 5-(tert-butyldimethylsilyloxy)-3-methylene-1-(pentafluorophenyl)pentan-1-ol

There total 1 articles about 5-(tert-butyldimethylsilyloxy)-3-methylene-1-(pentafluorophenyl)pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 653-37-2
perfluorobenzaldehyde

: 74915-94-9
1-(tert-butyldimethylsiloxy)-3-methyl-3-butene

: 1358895-39-2
3-methylidene-1-(pentafluorophenyl)pentane-1,5-diol

: 1358895-33-6
5-(tert-butyldimethylsilyloxy)-3-methylene-1-(pentafluorophenyl)pentan-1-ol

Guidance literature:: With dimethylaluminum chloride; In hexane; dichloromethane; at 0 - 20 ℃; for 27h; Inert atmosphere;
DOI:10.1002/ejoc.201100961

Reference yield: 71.0%

: 1358895-33-6
5-(tert-butyldimethylsilyloxy)-3-methylene-1-(pentafluorophenyl)pentan-1-ol

: 1358895-39-2
3-methylidene-1-(pentafluorophenyl)pentane-1,5-diol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 27h;
DOI:10.1002/ejoc.201100961

Reference yield:

: 1358895-33-6
5-(tert-butyldimethylsilyloxy)-3-methylene-1-(pentafluorophenyl)pentan-1-ol

: (2R,3aS,6aR)-2-(pentafluorophenyl)perhydrofuro[2,3-b]furan

: (2S,3aS,6aR)-2-(pentafluorophenyl)perhydrofuro[2,3-b]furan

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 27 h / 0 - 20 °C

2: dihydrogen peroxide; copper dichloride; palladium dichloride / methanol / 24 h / 72 °C

With tetrabutyl ammonium fluoride; dihydrogen peroxide; copper dichloride; palladium dichloride; In tetrahydrofuran; methanol; 2: Wacker type reaction;
DOI:10.1002/ejoc.201100961