3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide

Base Information

Chemical Name:3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide
CAS No.:957111-64-7
Molecular Formula:C₁₉H₁₆ClF₄NO₂
Molecular Weight:401.788
Hs Code.:

Synonyms:3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide

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Chemical Property of 3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide

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Technology Process of 3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide

There total 1 articles about 3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 957111-71-6
3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-hydroxybutyl]-N-methyl-5-(trifluoromethyl)benzamide

: 957111-64-7
3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide

Guidance literature:: 3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-hydroxybutyl]-N-methyl-5-(trifluoromethyl)benzamide; With pyridine-SO₃ complex; triethylamine; In dimethyl sulfoxide; at 20 ℃;

With sulfuric acid; In tert-butyl methyl ether; water; for 0.416667h;

Reference yield: 69.0%

: 957111-64-7
3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide

: 178312-50-0
3-((N)-morpholino)azetidine hydrochloride

: 3-Chloro-N-[(2S)-2-(4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl]-N-methyl-5-(trifluoromethyl)benzamide

Guidance literature:: 3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide; 3-((N)-morpholino)azetidine hydrochloride; With triethylamine; In methanol; at 20 ℃; for 0.5h;

With methanol; sodium tris(acetoxy)borohydride; at 20 ℃; for 2h;

Reference yield: 60.0%

: 957111-64-7
3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide

: 957127-69-4
1-acetyl-4-azetidin-3-ylpiperazine hydrochloride

: 3-Chloro-N-{(2S)-2-(4-fluorophenyl)-4-[3-(4-acetylpiperazin-1-yl)azetidin-1-yl]butyl}-N-methyl-5-(trifluoromethyl)benzamide

Guidance literature:: 3-chloro-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-N-methyl-5-(trifluoromethyl)-benzamide; 1-acetyl-4-azetidin-3-ylpiperazine hydrochloride; With triethylamine; In methanol; at 20 ℃; for 0.5h;

With methanol; sodium tris(acetoxy)borohydride; at 20 ℃; for 1h;

With water; sodium hydrogencarbonate; In dichloromethane;