6-(N-(4-amino-3-chlorophenyl)methanesulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Base Information

Chemical Name:6-(N-(4-amino-3-chlorophenyl)methanesulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide
CAS No.:1423007-33-3
Molecular Formula:C₂₆H₂₃Cl₂N₃O₄S
Molecular Weight:544.458
Hs Code.:

Synonyms:6-(N-(4-amino-3-chlorophenyl)methanesulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

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Chemical Property of 6-(N-(4-amino-3-chlorophenyl)methanesulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

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Technology Process of 6-(N-(4-amino-3-chlorophenyl)methanesulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

There total 15 articles about 6-(N-(4-amino-3-chlorophenyl)methanesulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1423007-32-2
6-(N-(3-chloro-4-nitrophenyl)methanesulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

: 1423007-33-3
6-(N-(4-amino-3-chlorophenyl)methanesulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: With 5 % platinum carbon sulfide; hydrogen; In tetrahydrofuran; methanol; for 18h; under 2327.23 Torr;

Reference yield:

: 1331943-23-7
5-cyclopropyl-2-(4-chlorophenyl)-6-(methylsulfonamido)benzofuran-3-carboxylic acid

: 1423007-33-3
6-(N-(4-amino-3-chlorophenyl)methanesulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 2 h

2.1: potassium carbonate / water; 1,2-dimethoxyethane / 20 - 100 °C / Sealed tube

3.1: hydrogen; 5 % platinum carbon sulfide / tetrahydrofuran; methanol / 18 h / 2327.23 Torr

With 5 % platinum carbon sulfide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1331943-24-8
2-(4-chlorophenyl)-5-cyclopropyl-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide

: 1423007-33-3
6-(N-(4-amino-3-chlorophenyl)methanesulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / water; 1,2-dimethoxyethane / 20 - 100 °C / Sealed tube

2: hydrogen; 5 % platinum carbon sulfide / tetrahydrofuran; methanol / 18 h / 2327.23 Torr

With 5 % platinum carbon sulfide; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water;