(E)-7-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-5-hydroxy-3-oxo-hept-6-enoic acid ethyl ester

Base Information

Chemical Name:(E)-7-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-5-hydroxy-3-oxo-hept-6-enoic acid ethyl ester
CAS No.:121660-86-4
Molecular Formula:C₂₇H₂₇ClFNO₄
Molecular Weight:483.967
Hs Code.:

Synonyms:(E)-7-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-5-hydroxy-3-oxo-hept-6-enoic acid ethyl ester

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Chemical Property of (E)-7-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-5-hydroxy-3-oxo-hept-6-enoic acid ethyl ester

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Technology Process of (E)-7-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-5-hydroxy-3-oxo-hept-6-enoic acid ethyl ester

There total 6 articles about (E)-7-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-5-hydroxy-3-oxo-hept-6-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141-97-9
ethyl acetoacetate

: 121660-62-6
(E)-3-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-propenal

: 121660-86-4
(E)-7-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-5-hydroxy-3-oxo-hept-6-enoic acid ethyl ester

Guidance literature:: With n-butyllithium; sodium hydride; Yield given. Multistep reaction; 1.) THF, 0 deg C, 2.) hexane, -78 deg C, 1 h;
DOI:10.1021/jm00105a057

Reference yield:

: 121660-10-4
[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-methanol

: 121660-86-4
(E)-7-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-5-hydroxy-3-oxo-hept-6-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium chlorochromate; sodium acetate / CH₂Cl₂ / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: tetrahydrofuran; hexane / -78 °C

3.1: p-toluenesulfonic acid / tetrahydrofuran; H₂O / 20 °C

4.1: NaH; n-BuLi / tetrahydrofuran; hexane / -10 °C

With n-butyllithium; sodium acetate; sodium hydride; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1016/S0968-0896(01)00198-5

Reference yield:

: 121660-36-4
6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinoline-3-carbaldehyde

: 121660-86-4
(E)-7-[6-Chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-5-hydroxy-3-oxo-hept-6-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 °C

2.1: p-toluenesulfonic acid / tetrahydrofuran; H₂O / 20 °C

3.1: NaH; n-BuLi / tetrahydrofuran; hexane / -10 °C

With n-butyllithium; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; water;
DOI:10.1016/S0968-0896(01)00198-5