4-Nitro-benzoic acid (2S,3S)-3-[(R)-4-benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranylmethyl ester

Base Information

Chemical Name:4-Nitro-benzoic acid (2S,3S)-3-[(R)-4-benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranylmethyl ester
CAS No.:1053252-58-6
Molecular Formula:C₂₅H₃₁NO₈
Molecular Weight:473.523
Hs Code.:

Synonyms:4-Nitro-benzoic acid (2S,3S)-3-[(R)-4-benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranylmethyl ester

Suppliers and Price of 4-Nitro-benzoic acid (2S,3S)-3-[(R)-4-benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Nitro-benzoic acid (2S,3S)-3-[(R)-4-benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranylmethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-Nitro-benzoic acid (2S,3S)-3-[(R)-4-benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranylmethyl ester

There total 7 articles about 4-Nitro-benzoic acid (2S,3S)-3-[(R)-4-benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 122-04-3
4-nitro-benzoyl chloride

: {(2S,3S)-3-[(R)-4-Benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranyl}-methanol

: 1053252-58-6
4-Nitro-benzoic acid (2S,3S)-3-[(R)-4-benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranylmethyl ester

Guidance literature:: With TEA; In dichloromethane;
DOI:10.1016/S0040-4039(98)00188-9

Reference yield:

: 126550-68-3
(R)-1-(benzyloxy)hex-5-en-2-ol

: 1053252-58-6
4-Nitro-benzoic acid (2S,3S)-3-[(R)-4-benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H(+) / CH₂Cl₂

2: NMO, NaIO₄ / OsO₄ / tetrahydrofuran; H₂O

3: 89 percent / NaH / 1,2-dimethoxy-ethane; benzene / 0 °C

4: 99 percent / diisobutylaluminum hydride / CH₂Cl₂ / -78 °C

5: 93 percent / L-(+)-diisopropyl tartrate, Ti(OPr-i)4, TBHP / CH₂Cl₂ / -25 °C

6: 98 percent / TEA / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; N-methyl-2-indolinone; L-(+)-diisopropyl tartrate; TEA; hydrogen cation; sodium hydride; diisobutylaluminium hydride; osmium(VIII) oxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; benzene;
DOI:10.1016/S0040-4039(98)00188-9

Reference yield:

: 14618-80-5
(R)-benzyl glycidol

: 1053252-58-6
4-Nitro-benzoic acid (2S,3S)-3-[(R)-4-benzyloxy-3-(2-ethoxy-ethoxy)-butyl]-oxiranylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / CuBr / tetrahydrofuran / 0 °C

2: H(+) / CH₂Cl₂

3: NMO, NaIO₄ / OsO₄ / tetrahydrofuran; H₂O

4: 89 percent / NaH / 1,2-dimethoxy-ethane; benzene / 0 °C

5: 99 percent / diisobutylaluminum hydride / CH₂Cl₂ / -78 °C

6: 93 percent / L-(+)-diisopropyl tartrate, Ti(OPr-i)4, TBHP / CH₂Cl₂ / -25 °C

7: 98 percent / TEA / CH₂Cl₂

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; N-methyl-2-indolinone; L-(+)-diisopropyl tartrate; TEA; hydrogen cation; sodium hydride; diisobutylaluminium hydride; osmium(VIII) oxide; copper(I) bromide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; benzene;
DOI:10.1016/S0040-4039(98)00188-9