trans-N-<2-(2'-hydroxycyclopentyl)ethyl>-N-methyl-p-nitrophenylaniline O-methanesulfonate

Base Information

Chemical Name:trans-N-<2-(2'-hydroxycyclopentyl)ethyl>-N-methyl-p-nitrophenylaniline O-methanesulfonate
CAS No.:121374-65-0
Molecular Formula:C₁₅H₂₂N₂O₅S
Molecular Weight:342.416
Hs Code.:

Synonyms:trans-N-<2-(2'-hydroxycyclopentyl)ethyl>-N-methyl-p-nitrophenylaniline O-methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-N-<2-(2'-hydroxycyclopentyl)ethyl>-N-methyl-p-nitrophenylaniline O-methanesulfonate

Chemical Property:

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Technology Process of trans-N-<2-(2'-hydroxycyclopentyl)ethyl>-N-methyl-p-nitrophenylaniline O-methanesulfonate

There total 7 articles about trans-N-<2-(2'-hydroxycyclopentyl)ethyl>-N-methyl-p-nitrophenylaniline O-methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 124-63-0
methanesulfonyl chloride

: 121374-63-8,121374-64-9
trans-N-<2-(2'-hydroxycyclopentyl)ethyl>-N-methyl-p-nitroaniline

: 121374-65-0
trans-N-<2-(2'-hydroxycyclopentyl)ethyl>-N-methyl-p-nitrophenylaniline O-methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 4 ℃; for 18h;
DOI:10.1021/jo00275a034

Reference yield:

: 54154-07-3
9-(2-hydroxyethyl)-1,4-dioxaspiro<4.4>nonane

: 121374-65-0
trans-N-<2-(2'-hydroxycyclopentyl)ethyl>-N-methyl-p-nitrophenylaniline O-methanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: triphenylphosphine, diethyl azodicarboxylate (DEAD) / tetrahydrofuran / 48 h / Ambient temperature

2: 85percent hydrazine hydrate / methanol / 16 h / Heating

3: 52 percent / K₂CO₃ / acetonitrile / 24 h / Heating

4: 85 percent / sodium hydride / tetrahydrofuran / 16 h / Ambient temperature

5: 83 percent / p-toluenesulfonic acid monohydrate / acetone / 16 h / Heating

6: 69 percent / sodium borohydride / methanol; tetrahydrofuran / 18 h / Ambient temperature

7: 89 percent / triethylamine / CH₂Cl₂ / 18 h / 4 °C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jo00275a034

Reference yield:

: 121374-55-8
2-(2'-oxocyclopentyl)ethylamine ethylene ketal

: 121374-65-0
trans-N-<2-(2'-hydroxycyclopentyl)ethyl>-N-methyl-p-nitrophenylaniline O-methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / K₂CO₃ / acetonitrile / 24 h / Heating

2: 85 percent / sodium hydride / tetrahydrofuran / 16 h / Ambient temperature

3: 83 percent / p-toluenesulfonic acid monohydrate / acetone / 16 h / Heating

4: 69 percent / sodium borohydride / methanol; tetrahydrofuran / 18 h / Ambient temperature

5: 89 percent / triethylamine / CH₂Cl₂ / 18 h / 4 °C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jo00275a034