2-deuteriobenzoic acid

Base Information

• Chemical Name: 2-deuteriobenzoic acid
• CAS No.: 4551-39-7
• Molecular Formula: C₇H₆O₂
• Molecular Weight: 123.115
• Mol file: 4551-39-7.mol

Synonyms:2-deuteriobenzoic acid

Chemical Property of 2-deuteriobenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-deuteriobenzoic acid

There total 16 articles about 2-deuteriobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Iodobenzoic acid (88-67-5) → 2-deuteriobenzoic acid (4551-39-7)

Guidance literature:

With sodium hypophosphite; diclazuril; potassium carbonate; isobutyric Acid; α,α'-azodiizobutyramidine-dihydrochloride; In water-d2; for 5h; Heating;

DOI:10.1246/bcsj.74.225

Reference yield: 98.0%

ortho-chlorobenzoic acid (118-91-2) → 2-deuteriobenzoic acid (4551-39-7)

Guidance literature:

With hydrogen; water-d2; triethylamine; palladium on activated charcoal; at 20 ℃;

DOI:10.1021/ol048591b

Reference yield: 94.0%

2-bromobenzoic-acid (88-65-3) → 2-deuteriobenzoic acid (4551-39-7)

Guidance literature:

With 1,2-propylene cyclic carbonate; water-d2; at 100 ℃; under 75007.5 Torr; chemoselective reaction; Flow reactor; Green chemistry;

DOI:10.1039/c8gc03192d

upstream raw materials:

2-deuteriotoluene

2-bromophenyl methyl ketone

ortho-chlorobenzoic acid

2-bromobenzoic-acid

Refernces

• 1、 Masson,Dormoy. "Synthesis of ortho deuterated phenylisocyanate under mild conditions". . p. 785 - 790. Retrieved 1979.
• 2、 -. "Method for synthesizing deuterated compound in aqueous phase solvent". Paragraph 0092-0097; 0143; 0146; 0147; 0150; 0172-0174. . Retrieved 2021/05/12.
• 3、 Orsy, Gy?rgy,Fül?p, Ferenc,Mándity, István M.. "Continuous-flow catalytic deuterodehalogenation carried out in propylene carbonate". supporting information. p. 956 - 961. Retrieved 2019/03/11.