5-O-benzoyl-1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide

Base Information

• Chemical Name: 5-O-benzoyl-1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide
• CAS No.: 76374-28-2
• Molecular Formula: C₂₀H₂₅NO₆
• Molecular Weight: 375.422
• Mol file: 76374-28-2.mol

Synonyms:5-O-benzoyl-1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide

Chemical Property of 5-O-benzoyl-1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-O-benzoyl-1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide

There total 4 articles about 5-O-benzoyl-1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide (76374-27-1) + benzoyl chloride (98-88-4) → 5-O-benzoyl-1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide (76374-28-2)

Guidance literature:

With pyridine; for 48h; Ambient temperature;

DOI:10.1039/P19810001782

Reference yield:

D-(-)-quinic acid (77-95-2) → 5-O-benzoyl-1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide (76374-28-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / acetyl chloride / 1 h / Heating

2: 74 percent / NH₃ / methanol / 48 h

3: 1.) hydrogen chloride, 2.) lead carbonate, MgSO₄ / 1.) 48 h, 2.) 2 h

4: 86 percent / pyridine / 48 h / Ambient temperature

With pyridine; hydrogenchloride; lead Carbonate; ammonia; magnesium sulfate; acetyl chloride; In methanol;

DOI:10.1039/P19810001782

Reference yield:

methyl (-)-quinate (191916-39-9) → 5-O-benzoyl-1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide (76374-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / NH₃ / methanol / 48 h

2: 1.) hydrogen chloride, 2.) lead carbonate, MgSO₄ / 1.) 48 h, 2.) 2 h

3: 86 percent / pyridine / 48 h / Ambient temperature

With pyridine; hydrogenchloride; lead Carbonate; ammonia; magnesium sulfate; In methanol;

DOI:10.1039/P19810001782

upstream raw materials:

1,1'-ON-isopropylidene-3,4-O-isopropylidenequinamide

benzoyl chloride

D-(-)-quinic acid

methyl (-)-quinate

Downstream raw materials:

(5R,8R)-8-benzoyloxy-6-hydroxymethyl-2,2-dimethyl-1-oxa-3-azaspiro<4,4>non-6-en-4-one

(5R,8R)-8-benzoyloxy-2,2-dimethyl-4-oxo-1-oxa-3-azaspiro<4,4>non-6-ene-6-carbaldehyde

(4R)-4-hydroxy-2-hydroxymethylcyclopent-2-en-1-one

5-O-benzoyl-1,1'-ON-isopropylidenequinamide