tert-butyl N2-(tert-butoxycarbonyl)-N1-{[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}-L-α-asparaginate

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Chemical Name:tert-butyl N2-(tert-butoxycarbonyl)-N1-{[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}-L-α-asparaginate
CAS No.:870893-65-5
Molecular Formula:C₃₄H₄₁FN₈O₈
Molecular Weight:708.747
Hs Code.:

tert-butyl N2-(tert-butoxycarbonyl)-N1-{[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}-L-α-asparaginate

Synonyms:tert-butyl N2-(tert-butoxycarbonyl)-N1-{[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}-L-α-asparaginate

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Chemical Property of tert-butyl N2-(tert-butoxycarbonyl)-N1-{[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}-L-α-asparaginate

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Technology Process of tert-butyl N2-(tert-butoxycarbonyl)-N1-{[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}-L-α-asparaginate

There total 17 articles about tert-butyl N2-(tert-butoxycarbonyl)-N1-{[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}-L-α-asparaginate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870893-58-6
(5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

: 1676-90-0
Boc-Asp(OtBu)-OH

: 870893-65-5
tert-butyl N2-(tert-butoxycarbonyl)-N1-{[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}-L-α-asparaginate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

Reference yield:

: 501939-95-3
(5R)-3-(3-fluoro-4-iodophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

: 870893-65-5
tert-butyl N2-(tert-butoxycarbonyl)-N1-{[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}-L-α-asparaginate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 0.67 h / 80 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 1 h / 85 °C

3: hydrogenchloride / 1,4-dioxane; DMF (N,N-dimethyl-formamide) / 18 h

4: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

With hydrogenchloride; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); water; dimethyl sulfoxide;

Reference yield:

: acetic acid (5R)-3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-ylmethyl ester

: 870893-65-5
tert-butyl N2-(tert-butoxycarbonyl)-N1-{[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}-L-α-asparaginate

Guidance literature:: Multi-step reaction with 8 steps

1: methanol; potassium carbonate / dichloromethane / 0.42 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: sodium azide / DMF (N,N-dimethyl-formamide) / 75 °C

4: 1,4-dioxane / 100 °C

5: triethylamine / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1.5 h / 100 °C

6: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 1 h / 85 °C

7: hydrogenchloride / 1,4-dioxane; DMF (N,N-dimethyl-formamide) / 18 h

8: N-ethyl-N,N-diisopropylamine; HATU / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

With hydrogenchloride; methanol; sodium azide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); dichloromethane; water;