(1'R)-(2E)-3-methyl-3-(4'-methylcyclohexen-3'-yl)-propen-2-al-1

Base Information

• Chemical Name: (1'R)-(2E)-3-methyl-3-(4'-methylcyclohexen-3'-yl)-propen-2-al-1
• CAS No.: 73088-68-3
• Molecular Formula: C₁₁H₁₆O
• Molecular Weight: 164.247
• Mol file: 73088-68-3.mol

Synonyms:(1'R)-(2E)-3-methyl-3-(4'-methylcyclohexen-3'-yl)-propen-2-al-1

Chemical Property of (1'R)-(2E)-3-methyl-3-(4'-methylcyclohexen-3'-yl)-propen-2-al-1

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'R)-(2E)-3-methyl-3-(4'-methylcyclohexen-3'-yl)-propen-2-al-1

There total 4 articles about (1'R)-(2E)-3-methyl-3-(4'-methylcyclohexen-3'-yl)-propen-2-al-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-limonene (5989-27-5,555-08-8,8022-90-0,9003-73-0,95327-98-3) → (1'R)-(2E)-3-methyl-3-(4'-methylcyclohexen-3'-yl)-propen-2-al-1 (73088-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi; TMEDA / hexane / 20 °C

1.2: hexane / -78 - 0 °C

2.1: activity grade I alumina / diethyl ether / 2 h

With aluminum oxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; 1.1: Metallation / 1.2: Formylation / 2.1: Isomerization;

Reference yield:

(R)-(+)-3-(4-methyl-3-cyclohexen-1-yl)-3-buten-1-ol (77614-30-3) → (R)-3-(4-methyl-cyclohex-3-enyl)-but-3-enal (77614-31-4) + (1'R)-(2Z)-3-methyl-3-(4'-methylcyclohexene-3'-yl)-propen-2-al-1 (77647-35-9) + (1'R)-(2E)-3-methyl-3-(4'-methylcyclohexen-3'-yl)-propen-2-al-1 (73088-68-3)

Guidance literature:

With sodium acetate; pyridinium chlorochromate; In dichloromethane; for 2h; Yield given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1016/0040-4020(80)88037-9

Reference yield:

(R)-3-(4-methyl-cyclohex-3-enyl)-but-3-enal (77614-31-4) → (1'R)-(2Z)-3-methyl-3-(4'-methylcyclohexene-3'-yl)-propen-2-al-1 (77647-35-9) + (1'R)-(2E)-3-methyl-3-(4'-methylcyclohexen-3'-yl)-propen-2-al-1 (73088-68-3)

Guidance literature:

With aluminum oxide; In diethyl ether; for 2h;

upstream raw materials:

(R)-(+)-3-(4-methyl-3-cyclohexen-1-yl)-3-buten-1-ol

D-limonene

N,N-dimethyl-formamide

(R)-3-(4-methyl-cyclohex-3-enyl)-but-3-enal

Downstream raw materials:

(R)-4-((S)-1,5-Dimethyl-3-oxo-hexyl)-cyclohex-1-enecarbaldehyde

(+)-Epitodomatuic acid

(+)-epijuvabione

(S)-3-((R)-4-methylcyclohex-3-en-1-yl)butanal