N-(2-ethyl-4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

Base Information

Chemical Name:N-(2-ethyl-4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine
CAS No.:1449664-78-1
Molecular Formula:C₂₂H₂₇N₅O₂S
Molecular Weight:425.555
Hs Code.:

Synonyms:N-(2-ethyl-4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

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Chemical Property of N-(2-ethyl-4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

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Technology Process of N-(2-ethyl-4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

There total 10 articles about N-(2-ethyl-4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607373-83-1
2-chloro-4-methoxy-5-nitro-pyridine

: 1449664-78-1
N-(2-ethyl-4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: iron; acetic acid / 1 h / 50 - 80 °C

3.1: 4 h / 100 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.33 h / 0 °C

5.2: 0.5 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

7.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; iron; acetic acid; triethylamine; trifluoroacetic acid; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1449506-75-5
N-(2-ethyl-4-(1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridine-amine

: 124-63-0
methanesulfonyl chloride

: 1449664-78-1
N-(2-ethyl-4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h;

Reference yield:

: 1449506-72-2
tert-butyl 4-(4-amino-3-ethylphenyl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1449664-78-1
N-(2-ethyl-4-(1-(methylsulfonyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-6-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; triethylamine; trifluoroacetic acid; sodium t-butanolate; XPhos; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;