4-[(5-{[4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinyl]methyl}-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide

Base Information

• Chemical Name: 4-[(5-{[4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinyl]methyl}-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide
• CAS No.: 1150111-48-0
• Molecular Formula: C₃₅H₃₇F₂N₅O₄
• Molecular Weight: 629.707
• Mol file: 1150111-48-0.mol

Synonyms:4-[(5-{[4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinyl]methyl}-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide

Chemical Property of 4-[(5-{[4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinyl]methyl}-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(5-{[4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinyl]methyl}-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide

There total 2 articles about 4-[(5-{[4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinyl]methyl}-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-[(5-formyl-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide (1150111-58-2) + N-(3-fluorophenyl)-N-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride → 4-[(5-{[4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinyl]methyl}-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide (1150111-48-0)

Guidance literature:

4-[(5-formyl-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide; N-(3-fluorophenyl)-N-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride; With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 16h;

With water; potassium carbonate; In dichloromethane;

Reference yield: 64.0%

4-[(5-formyl-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide (1150111-58-2) + N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride (1150111-62-8) → 4-[(5-{[4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinyl]methyl}-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide (1150111-48-0)

Guidance literature:

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 16h;

upstream raw materials:

4-[(5-formyl-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide

N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride