N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride

Base Information

• Chemical Name: N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride
• CAS No.: 1150111-62-8
• Molecular Formula: C₁₈H₁₉F₂N₃O*ClH
• Molecular Weight: 367.826
• Mol file: 1150111-62-8.mol

Synonyms:N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride

Chemical Property of N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride

There total 1 articles about N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,1-dimethylethyl 4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinecarboxylate (1161086-48-1) → N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride (1150111-62-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield: 64.0%

4-[(5-formyl-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide (1150111-58-2) + N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride (1150111-62-8) → 4-[(5-{[4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinyl]methyl}-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide (1150111-48-0)

Guidance literature:

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 16h;

Reference yield: 59.0%

2-methyl-6-{[4-(4-morpholinylcarbonyl)phenyl]oxy}-3-pyridinecarbaldehyde (1150111-59-3) + N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-4-piperidinylurea hydrochloride (1150111-62-8) → N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-{1-[(2-methyl-6-{[4-(4-morpholinylcarbonyl)phenyl]oxy}-3-pyridinyl)methyl]-4-piperidinyl}urea (1150111-49-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 16h;

upstream raw materials:

1,1-dimethylethyl 4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinecarboxylate

Downstream raw materials:

4-[(5-{[4-((3-fluorophenyl){[(4-fluorophenyl)amino]carbonyl}amino)-1-piperidinyl]methyl}-6-methyl-2-pyridinyl)oxy]-N-[2-(methyloxy)ethyl]benzamide

N-(3-fluorophenyl)-N'-(4-fluorophenyl)-N-{1-[(2-methyl-6-{[4-(4-morpholinylcarbonyl)phenyl]oxy}-3-pyridinyl)methyl]-4-piperidinyl}urea