1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-methoxybenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Base Information

Chemical Name:1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-methoxybenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one
CAS No.:1417527-30-0
Molecular Formula:C₃₃H₃₀F₃N₅O₂S
Molecular Weight:617.695
Hs Code.:

Synonyms:1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-methoxybenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Chemical Property of 1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-methoxybenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Technology Process of 1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-methoxybenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

There total 10 articles about 1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-methoxybenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417526-73-8
1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-thioxo-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

: 824-94-2
p-methoxybenzyl chloride

: 1417527-30-0
1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-methoxybenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: With potassium carbonate; In acetone; for 1h; Reflux;

Reference yield:

: 1417526-69-2
(4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methanol

: 1417527-30-0
1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-methoxybenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Reflux

2: triphenylphosphine / tetrahydrofuran; water / 20 °C

3: tetraethoxy orthosilicate / ethanol / 5 h / Inert atmosphere; Reflux

4: N,N-dimethyl-formamide / 8 h / 140 °C / Inert atmosphere

5: potassium carbonate / acetone / 1 h / Reflux

With tetraethoxy orthosilicate; diphenyl phosphoryl azide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1417526-70-5
3-(azido methyl)-4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazole

: 1417527-30-0
1-((4-ethyl-5-(4'-(trifluoromethyl)biphenyl-4-yl)-4H-1,2,4-triazol-3-yl)methyl)-2-(4-methoxybenzylthio)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine / tetrahydrofuran; water / 20 °C

2: tetraethoxy orthosilicate / ethanol / 5 h / Inert atmosphere; Reflux

3: N,N-dimethyl-formamide / 8 h / 140 °C / Inert atmosphere

4: potassium carbonate / acetone / 1 h / Reflux

With tetraethoxy orthosilicate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone;