Technology Process of 1-((1R,3R,4R,5R,11R)-7,7,9,9-Tetraisopropyl-4-phenylselanyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-3-yl)-1H-pyrimidine-2,4-dione
There total 8 articles about 1-((1R,3R,4R,5R,11R)-7,7,9,9-Tetraisopropyl-4-phenylselanyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-3-yl)-1H-pyrimidine-2,4-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
![1-((1R,3R,4R,5R,11R)-7,7,9,9-Tetraisopropyl-4-phenylselanyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0<sup>1,5</sup>]tetradec-3-yl)-1H-pyrimidine-2,4-dione](/Databaselist/images/loading.webp)
-
849113-15-1
1-((1R,3R,4R,5R,11R)-7,7,9,9-Tetraisopropyl-4-phenylselanyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-3-yl)-1H-pyrimidine-2,4-dione
- Guidance literature:
-
In
acetonitrile;
at 0 ℃;
for 1h;
DOI:10.1021/jo048071u
-
-
849113-15-1
1-((1R,3R,4R,5R,11R)-7,7,9,9-Tetraisopropyl-4-phenylselanyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-3-yl)-1H-pyrimidine-2,4-dione
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 77 percent / K2CO3; MeSO2NH2; K3Fe(CN)6 / DABCO; K2OsO2(OH)4 / 2-methyl-propan-2-ol; H2O / 20 °C
2: p-toluenesulfonic acid / 3 h / Heating
3: 219 mg / LiOH / tetrahydrofuran; H2O / 4 h
4: 22 percent Spectr. / aluminium isopropoxide / propan-2-ol / 17 h / Heating
5: 70 percent / HMPA; t-BuLi / tetrahydrofuran; pentane / 7 h / -78 - 0 °C
6: 91 percent / AgOTf; 2,4,6-collidine / dimethylformamide / 3 h / 20 °C
7: 80 percent / acetonitrile / 1 h / 0 °C
With
2,4,6-trimethyl-pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; methanesulfonamide; tert.-butyl lithium; silver trifluoromethanesulfonate; aluminum isopropoxide; potassium carbonate; toluene-4-sulfonic acid; potassium hexacyanoferrate(III);
1,4-diaza-bicyclo[2.2.2]octane; potassium dioxotetrahydroxoosmate(VI);
In
tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; tert-butyl alcohol; pentane;
4: Meerwein-Ponndorf-Verley reduction;
DOI:10.1021/jo048071u
-
-
849113-15-1
1-((1R,3R,4R,5R,11R)-7,7,9,9-Tetraisopropyl-4-phenylselanyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-3-yl)-1H-pyrimidine-2,4-dione
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 22 percent Spectr. / aluminium isopropoxide / propan-2-ol / 17 h / Heating
2: 70 percent / HMPA; t-BuLi / tetrahydrofuran; pentane / 7 h / -78 - 0 °C
3: 91 percent / AgOTf; 2,4,6-collidine / dimethylformamide / 3 h / 20 °C
4: 80 percent / acetonitrile / 1 h / 0 °C
With
2,4,6-trimethyl-pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium; silver trifluoromethanesulfonate; aluminum isopropoxide;
In
tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; pentane;
1: Meerwein-Ponndorf-Verley reduction;
DOI:10.1021/jo048071u
