5-(8-chloro-6-(trifluoromethyl)imidazol[1,2-a]pyridine-2-yl)-3-(2,5-dichloro-4-methoxyphenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:5-(8-chloro-6-(trifluoromethyl)imidazol[1,2-a]pyridine-2-yl)-3-(2,5-dichloro-4-methoxyphenyl)-1,2,4-oxadiazole
CAS No.:1228375-15-2
Molecular Formula:C₁₇H₈Cl₃F₃N₄O₂
Molecular Weight:463.63
Hs Code.:

Synonyms:5-(8-chloro-6-(trifluoromethyl)imidazol[1,2-a]pyridine-2-yl)-3-(2,5-dichloro-4-methoxyphenyl)-1,2,4-oxadiazole

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Chemical Property of 5-(8-chloro-6-(trifluoromethyl)imidazol[1,2-a]pyridine-2-yl)-3-(2,5-dichloro-4-methoxyphenyl)-1,2,4-oxadiazole

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Technology Process of 5-(8-chloro-6-(trifluoromethyl)imidazol[1,2-a]pyridine-2-yl)-3-(2,5-dichloro-4-methoxyphenyl)-1,2,4-oxadiazole

There total 7 articles about 5-(8-chloro-6-(trifluoromethyl)imidazol[1,2-a]pyridine-2-yl)-3-(2,5-dichloro-4-methoxyphenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.1%

: 1228376-22-4
2,5-dichloro-N-hydroxy-4-methoxybenzamidine

: 353258-35-2
8-chloro-6-(trifluoromethyl)-imidazo[1,2-a]pyridine-2-carboxylic acid

: 1228375-15-2
5-(8-chloro-6-(trifluoromethyl)imidazol[1,2-a]pyridine-2-yl)-3-(2,5-dichloro-4-methoxyphenyl)-1,2,4-oxadiazole

Guidance literature:: 8-chloro-6-(trifluoromethyl)-imidazo[1,2-a]pyridine-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.25h;

2,5-dichloro-N-hydroxy-4-methoxybenzamidine; In N,N-dimethyl-formamide; at 100 ℃; for 12h;

Reference yield: 33.0%

: 353258-35-2
8-chloro-6-(trifluoromethyl)-imidazo[1,2-a]pyridine-2-carboxylic acid

: C₈H₈Cl₂N₂O₂

: 1228375-15-2
5-(8-chloro-6-(trifluoromethyl)imidazol[1,2-a]pyridine-2-yl)-3-(2,5-dichloro-4-methoxyphenyl)-1,2,4-oxadiazole

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 100 ℃; for 12h;

Reference yield:

: 1940-42-7,79151-08-9
4-bromo-2,5-dichlorophenol

: 1228375-15-2
5-(8-chloro-6-(trifluoromethyl)imidazol[1,2-a]pyridine-2-yl)-3-(2,5-dichloro-4-methoxyphenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 4 h / 150 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 3 h / 20 °C

3.1: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / 80 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h

4.2: 12 h / 100 °C

With hydroxylamine hydrochloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide;