(2R,3R)-2-(tert-butyldimethylsilanyloxy)-1-[(4-methoxyphenyl)diphenylmethoxy]-3,4-dimethylpent-4-ene

Base Information

Chemical Name:(2R,3R)-2-(tert-butyldimethylsilanyloxy)-1-[(4-methoxyphenyl)diphenylmethoxy]-3,4-dimethylpent-4-ene
CAS No.:267236-40-8
Molecular Formula:C₃₃H₄₄O₃Si
Molecular Weight:516.796
Hs Code.:

Synonyms:(2R,3R)-2-(tert-butyldimethylsilanyloxy)-1-[(4-methoxyphenyl)diphenylmethoxy]-3,4-dimethylpent-4-ene

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Chemical Property of (2R,3R)-2-(tert-butyldimethylsilanyloxy)-1-[(4-methoxyphenyl)diphenylmethoxy]-3,4-dimethylpent-4-ene

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Technology Process of (2R,3R)-2-(tert-butyldimethylsilanyloxy)-1-[(4-methoxyphenyl)diphenylmethoxy]-3,4-dimethylpent-4-ene

There total 3 articles about (2R,3R)-2-(tert-butyldimethylsilanyloxy)-1-[(4-methoxyphenyl)diphenylmethoxy]-3,4-dimethylpent-4-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 267236-29-3
(2R,3R)-1-[(4-methoxyphenyl)diphenylmethoxy]-3,4-dimethylpent-4-en-2-ol

: 267236-40-8
(2R,3R)-2-(tert-butyldimethylsilanyloxy)-1-[(4-methoxyphenyl)diphenylmethoxy]-3,4-dimethylpent-4-ene

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 96h;
DOI:10.1021/ol0000197

Reference yield:

: 267236-28-2
(2S,3R)-2,3-epoxy-1-[(4-methoxyphenyl)diphenylmethoxy]butane

: 267236-40-8
(2R,3R)-2-(tert-butyldimethylsilanyloxy)-1-[(4-methoxyphenyl)diphenylmethoxy]-3,4-dimethylpent-4-ene

Guidance literature:: Multi-step reaction with 2 steps

1: CuBr*DMS; BF₃*Et₂O / tetrahydrofuran / 2 h / -78 - 20 °C

2: 92 percent / imidazole; DMAP / dimethylformamide / 96 h / 20 °C

With 1H-imidazole; dmap; copper(I) bromide dimethylsulfide complex; boron trifluoride diethyl etherate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Ring cleavage / 2: Substitution;
DOI:10.1021/ol0000197

Reference yield:

: (4-methoxyphenyl)diphenylmethyl chloride

: 267236-40-8
(2R,3R)-2-(tert-butyldimethylsilanyloxy)-1-[(4-methoxyphenyl)diphenylmethoxy]-3,4-dimethylpent-4-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent

2: CuBr*DMS; BF₃*Et₂O / tetrahydrofuran / 2 h / -78 - 20 °C

3: 92 percent / imidazole; DMAP / dimethylformamide / 96 h / 20 °C

With 1H-imidazole; dmap; copper(I) bromide dimethylsulfide complex; boron trifluoride diethyl etherate; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Ring cleavage / 3: Substitution;
DOI:10.1021/ol0000197