4,5-dimethoxy-2-nitrobenzyl (2,6-bis((E)-3-((tert-butyldimethylsilyl)oxy)prop-1-en-1-yl)-4-(hydroxymethyl)phenyl)carbamate

Base Information

Chemical Name:4,5-dimethoxy-2-nitrobenzyl (2,6-bis((E)-3-((tert-butyldimethylsilyl)oxy)prop-1-en-1-yl)-4-(hydroxymethyl)phenyl)carbamate
CAS No.:1590443-36-9
Molecular Formula:C₃₅H₅₄N₂O₉Si₂
Molecular Weight:702.993
Hs Code.:

Synonyms:4,5-dimethoxy-2-nitrobenzyl (2,6-bis((E)-3-((tert-butyldimethylsilyl)oxy)prop-1-en-1-yl)-4-(hydroxymethyl)phenyl)carbamate

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Chemical Property of 4,5-dimethoxy-2-nitrobenzyl (2,6-bis((E)-3-((tert-butyldimethylsilyl)oxy)prop-1-en-1-yl)-4-(hydroxymethyl)phenyl)carbamate

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Technology Process of 4,5-dimethoxy-2-nitrobenzyl (2,6-bis((E)-3-((tert-butyldimethylsilyl)oxy)prop-1-en-1-yl)-4-(hydroxymethyl)phenyl)carbamate

There total 5 articles about 4,5-dimethoxy-2-nitrobenzyl (2,6-bis((E)-3-((tert-butyldimethylsilyl)oxy)prop-1-en-1-yl)-4-(hydroxymethyl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 42855-00-5
nitroveratryloxycarbonyl chloride

: 1590443-37-0
(4-amino-3,5-bis((E)-3-((tert-butyldimethylsilyl)oxy)prop-1-en-1-yl)phenyl)methanol

: 1590443-36-9
4,5-dimethoxy-2-nitrobenzyl (2,6-bis((E)-3-((tert-butyldimethylsilyl)oxy)prop-1-en-1-yl)-4-(hydroxymethyl)phenyl)carbamate

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 2h;
DOI:10.1016/j.tetlet.2014.01.092

Reference yield:

: 94-09-7
p-aminoethylbenzoate

: 1590443-36-9
4,5-dimethoxy-2-nitrobenzyl (2,6-bis((E)-3-((tert-butyldimethylsilyl)oxy)prop-1-en-1-yl)-4-(hydroxymethyl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; silver sulfate / ethanol / 0.83 h / 20 °C

2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / 0 - 20 °C / Inert atmosphere

3: palladium diacetate; triphenylphosphine; potassium phosphate / 1,4-dioxane; water / 3 h

4: sodium hydrogencarbonate / water; dichloromethane / 2 h / 20 °C

With potassium phosphate; iodine; palladium diacetate; diisobutylaluminium hydride; sodium hydrogencarbonate; silver sulfate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.tetlet.2014.01.092

Reference yield:

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 1590443-36-9
4,5-dimethoxy-2-nitrobenzyl (2,6-bis((E)-3-((tert-butyldimethylsilyl)oxy)prop-1-en-1-yl)-4-(hydroxymethyl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; Schwartz's reagent / Inert atmosphere

2: palladium diacetate; triphenylphosphine; potassium phosphate / 1,4-dioxane; water / 3 h

3: sodium hydrogencarbonate / water; dichloromethane / 2 h / 20 °C

With potassium phosphate; Schwartz's reagent; palladium diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.tetlet.2014.01.092