propanoic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

Base Information

• Chemical Name: propanoic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester
• CAS No.: 1154062-00-6
• Molecular Formula: C₂₃H₃₀O₅
• Molecular Weight: 386.488
• Mol file: 1154062-00-6.mol

Synonyms:propanoic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

Chemical Property of propanoic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of propanoic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

There total 1 articles about propanoic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethanol (916525-73-0) + propionic acid (802294-64-0,79-09-4) → propanoic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester (1154062-00-6)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.02.004

Reference yield: 79.0%

propanoic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester (1154062-00-6) + benzyl bromide (100-39-0) → 2-methyl-3-phenylpropanoic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

Guidance literature:

propanoic acid (1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 1.5h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at -70 - 20 ℃; optical yield given as %de; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.02.004

upstream raw materials:

(1R,2S)-1,2-bis(4-methoxyphenyl)-2-(2-methylpropoxy)ethanol

propionic acid