C₂₂H₂₄Cl₂FNO₃

Base Information

• Chemical Name: C₂₂H₂₄Cl₂FNO₃
• CAS No.: 1620087-53-7
• Molecular Formula: C₂₂H₂₄Cl₂FNO₃
• Molecular Weight: 440.342
• Mol file: 1620087-53-7.mol

Synonyms:C₂₂H₂₄Cl₂FNO₃

Chemical Property of C₂₂H₂₄Cl₂FNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₄Cl₂FNO₃

There total 6 articles about C₂₂H₂₄Cl₂FNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluorophenol (367-12-4) + C17H23Cl2NO5S → C22H24Cl2FNO3 (1620087-53-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 12h;

DOI:10.1016/j.bmcl.2014.06.026

Reference yield:

2-fluorophenol (367-12-4) + C16H21Cl2NO3 (1620087-49-1) → C22H24Cl2FNO3 (1620087-53-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2014.06.026

Reference yield:

tert-butyl 3-(2-oxoethyl)azetidine-1-carboxylate (152537-04-7) → C22H24Cl2FNO3 (1620087-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2014.06.026

upstream raw materials:

2-fluorophenol

C₁₆H₂₁Cl₂NO₃

tert-butyl 3-(2-oxoethyl)azetidine-1-carboxylate

tert-butyl 3-(2-methoxy-2-oxo-ethyl)azetidine-1-carboxylate

Downstream raw materials:

3-(2-(3,4-dichlorophenyl)-2-(2-fluorophenoxy)ethyl)azetidine

Refernces