4-cyano-(4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl)benzene

Base Information

• Chemical Name: 4-cyano-(4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl)benzene
• CAS No.: 1083171-27-0
• Molecular Formula: C₁₂H₁₂N₄O
• Molecular Weight: 228.253
• Mol file: 1083171-27-0.mol

Synonyms:4-cyano-(4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl)benzene

Chemical Property of 4-cyano-(4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-cyano-(4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl)benzene

There total 2 articles about 4-cyano-(4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-azidobenzonitrile (18523-41-6) + pent-1-yn-5-ol (5390-04-5) → 4-cyano-(4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl)benzene (1083171-27-0)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; acetonitrile; at 80 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1055/s-2008-1078019

Reference yield:

4-Aminobenzonitrile (873-74-5) → 4-cyano-(4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl)benzene (1083171-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: copper(II) sulfate; sodium L-ascorbate / water; tetrahydrofuran; tert-butyl alcohol / 20 °C

With hydrogenchloride; copper(II) sulfate; sodium L-ascorbate; sodium nitrite; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1016/j.bmcl.2020.127372

Reference yield:

4-cyano-(4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl)benzene (1083171-27-0) + p-toluenesulfonyl chloride (98-59-9) → 4-cyano-(4-(3-(tosyloxy)propyl)-1H-1,2,3-triazol-1-yl)benzene

Guidance literature:

With dmap; triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2020.127372

upstream raw materials:

4-azidobenzonitrile

pent-1-yn-5-ol

4-Aminobenzonitrile