18523-41-6Relevant articles and documents
Tuning Molecular Vibrational Energy Flow within an Aromatic Scaffold via Anharmonic Coupling
Schmitz, Andrew J.,Pandey, Hari Datt,Chalyavi, Farzaneh,Shi, Tianjiao,Fenlon, Edward E.,Brewer, Scott H.,Leitner, David M.,Tucker, Matthew J.
, p. 10571 - 10581 (2019)
From guiding chemical reactivity in synthesis or protein folding to the design of energy diodes, intramolecular vibrational energy redistribution harnesses the power to influence the underlying fundamental principles of chemistry. To evaluate the ability
Quinazoline substituted 1, 2, 3-triazole derivative as well as pharmaceutical composition, preparation method and application thereof
-
Paragraph 0068-0072, (2022/03/31)
The invention discloses a quinazoline substituted 1, 2, 3-triazole derivative, the derivative is shown as a general formula (I), and the definition of each substituent group is shown in the specification. In addition, the invention also discloses a preparation method of the compound. The compound shown in the general formula (I) has an inhibiting effect on proliferation of tumor cells, also has an inhibiting effect on proliferation of human colon cancer (HCT-116) and human lung cancer cell strain (A549) cells, and can be used as an antitumor drug.
Triazole [5, 4-d] pyrimidone tricyclic compounds as well as preparation method and application thereof
-
Paragraph 0064; 0067-0070; 0074, (2021/07/09)
The invention relates to triazole [5, 4-d] pyrimidone tricyclic compounds as well as a preparation method and application thereof.The triazole [5, 4-d] pyrimidone tricyclic compounds are prepared by following steps: taking different substituted anilines a
Synthesis and antitumor activity of 1-substituted 1,2,3-triazole-mollugin derivatives
Hu, Jiang-Miao,Li, Hong-Mei,Liu, Shou-Jin,Luo, Han,Lv, Yong-Feng,Zhang, Hong
, (2021/06/11)
A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.