3-([2,2′-bipyridin]-4-yl)aniline

Base Information

• Chemical Name: 3-([2,2′-bipyridin]-4-yl)aniline
• CAS No.: 871335-42-1
• Molecular Formula: C₁₆H₁₃N₃
• Molecular Weight: 247.299
• Mol file: 871335-42-1.mol

Synonyms:3-([2,2′-bipyridin]-4-yl)aniline

Chemical Property of 3-([2,2′-bipyridin]-4-yl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-([2,2′-bipyridin]-4-yl)aniline

There total 7 articles about 3-([2,2′-bipyridin]-4-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(3-nitrophenyl)-2,2’-bipyridine (871335-41-0) → 3-([2,2′-bipyridin]-4-yl)aniline (871335-42-1)

Guidance literature:

4-(3-nitrophenyl)-2,2’-bipyridine; With palladium 10% on activated carbon; In ethanol; for 1h; Reflux;

With hydrazine hydrate; In ethanol; for 1h; Reflux;

DOI:10.1080/10610278.2011.638381

Reference yield:

3-nitro-benzaldehyde (99-61-6) → 3-([2,2′-bipyridin]-4-yl)aniline (871335-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 3 h / 0 °C

2.1: ammonium acetate / water / 5 h / Reflux

3.1: palladium 10% on activated carbon / ethanol / 1 h / Reflux

3.2: 1 h / Reflux

With palladium 10% on activated carbon; ammonium acetate; sodium hydroxide; In ethanol; water;

DOI:10.1039/c2cc17274g

Reference yield:

4-(3-nitrophenyl)-2-oxobut-3-enoic acid (1772-65-2) → 3-([2,2′-bipyridin]-4-yl)aniline (871335-42-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonium acetate / water / 5 h / Reflux

2.1: Heating

3.1: palladium 10% on activated carbon / ethanol / 1 h / Reflux

3.2: 1 h / Reflux

With palladium 10% on activated carbon; ammonium acetate; In ethanol; water;

DOI:10.1021/acs.inorgchem.0c01395

upstream raw materials:

4-(3-nitrophenyl)-2,2’-bipyridine

(E)-4-(3-nitrophenyl)-2-oxo-3-butenoic acid

3-nitro-benzaldehyde

1-(2-oxo-2-(2-pyridyl)ethyl)pyridinium iodide

Downstream raw materials:

bis-{N-[3-(2,2'-dipyridin-4-yl)phenyl]}-9,18,-methano-1,8-naphthalimido[b,f][1,5]diazocene

4-[N-(m-phenyl)-4-amino-1,8-napthalimide]-2,2'-bipyridine

4-[N-phenyl-4-nitro-1,8-naphthalimide]-2,2’-bipyridine

4-[3''-(4'''-tolylazo)phenyl]-2,2'-bipyridine

Refernces

• 1、 Elmes, Robert B. P.,Erby, Maria Luisa,Frimannsson, Daniel O.,Gunnlaugsson, Thorfinnur,Kitchen, Jonathan A.,Lawler, Mark,Quinn, Susan J.,Ryan, Gary J.,Williams, D. Clive. "Synthesis, Characterization, and Biological Profiling of Ruthenium(II)-Based 4-Nitro- And 4-Amino-1,8-naphthalimide Conjugates". supporting information. . Retrieved 2020/07/27.
• 2、 Elmes, Robert B. P.,Erby, Marialuisa,Bright, Sandra A.,Williams, D. Clive,Gunnlaugsson, Thorfinnur. "Photophysical and biological investigation of novel luminescent Ru(ii)-polypyridyl-1,8-naphthalimide Troeger's bases as cellular imaging agents". supporting information; experimental part. p. 2588 - 2590. Retrieved 2012/04/17.