(1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid methyl ester

Base Information

• Chemical Name: (1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid methyl ester
• CAS No.: 704913-80-4
• Molecular Formula: C₁₇H₁₃NO₅S
• Molecular Weight: 343.36
• Mol file: 704913-80-4.mol

Synonyms:(1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid methyl ester

Chemical Property of (1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid methyl ester

There total 1 articles about (1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(3-indolyl)oxoacetic acid methyl ester (18372-22-0) + benzenesulfonyl chloride (98-09-9) → (1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid methyl ester (704913-80-4)

Guidance literature:

2-(3-indolyl)oxoacetic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

benzenesulfonyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1021/jo049808i

Reference yield: 83.0%

(1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid methyl ester (704913-80-4) → (1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid (704913-81-5)

Guidance literature:

With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jo049808i

Reference yield:

(1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid methyl ester (704913-80-4) → N-[2-(1-benzenesulfonyl-1H-indol-3-yl)-2-oxo-acetyl]-N-furan-2-yl-carbamic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / KOTMS / tetrahydrofuran / 1 h / 20 °C

2: (COCl)2 / CH₂Cl₂ / 1 h / 20 °C

3: 0.3 g / Et₃N; DMAP / tetrahydrofuran / 1 h / 20 °C

With dmap; oxalyl dichloride; potassium trimethylsilonate; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo049808i

upstream raw materials:

2-(3-indolyl)oxoacetic acid methyl ester

benzenesulfonyl chloride

Downstream raw materials:

(1-benzenesulfonyl-1H-indol-3-yl)oxoacetic acid