3-carbomethoxymethylthio-4-(2-methoxyphenyl)-2-methyl-1-butene

Base Information

• Chemical Name: 3-carbomethoxymethylthio-4-(2-methoxyphenyl)-2-methyl-1-butene
• CAS No.: 99347-70-3
• Molecular Formula: C₁₅H₂₀O₃S
• Molecular Weight: 280.388
• Mol file: 99347-70-3.mol

Synonyms:3-carbomethoxymethylthio-4-(2-methoxyphenyl)-2-methyl-1-butene

Chemical Property of 3-carbomethoxymethylthio-4-(2-methoxyphenyl)-2-methyl-1-butene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-carbomethoxymethylthio-4-(2-methoxyphenyl)-2-methyl-1-butene

There total 5 articles about 3-carbomethoxymethylthio-4-(2-methoxyphenyl)-2-methyl-1-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Methyl thioglycolate (2365-48-2) + 1-(2-Chloro-3-methyl-but-3-enyl)-2-methoxy-benzene (99347-79-2) → 3-carbomethoxymethylthio-4-(2-methoxyphenyl)-2-methyl-1-butene (99347-70-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 15h; Ambient temperature;

DOI:10.1248/cpb.33.1930

Reference yield: 68.0%

sodium (2-methoxy-2-oxoethyl)sulfanide (42271-17-0) + 1-(2-Chloro-3-methyl-but-3-enyl)-2-methoxy-benzene (99347-79-2) → 3-carbomethoxymethylthio-4-(2-methoxyphenyl)-2-methyl-1-butene (99347-70-3)

Guidance literature:

In 1,2-dimethoxyethane; N,N-dimethyl-formamide; 0 deg C, 1 h, room temperature, 1 h;

DOI:10.1248/cpb.33.1930

Reference yield:

prenyl bromide (870-63-3) → 3-carbomethoxymethylthio-4-(2-methoxyphenyl)-2-methyl-1-butene (99347-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) Na / 1.) Et₂O, reflux, 1.5 h; 2.) DMF-DME, 0-15 deg C, 1.5 h

2: 1.) CCl₄, -20 deg C, 20 min; 2.) DMF, 60 deg C, 20 h

With sodium;

DOI:10.1248/cpb.33.1930

upstream raw materials:

sodium (2-methoxy-2-oxoethyl)sulfanide

1-(2-Chloro-3-methyl-but-3-enyl)-2-methoxy-benzene

Methyl thioglycolate

1-methoxy-2-(3-methylbut-2-en-1-yl)benzene

Downstream raw materials:

(E)-6-(2-Methoxy-phenyl)-4-methyl-hex-4-enoic acid methyl ester