4-(4-fluoro-phenyl)-6-(6-fluoro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine

Base Information

• Chemical Name: 4-(4-fluoro-phenyl)-6-(6-fluoro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine
• CAS No.: 896742-06-6
• Molecular Formula: C₂₀H₁₈F₂N₄
• Molecular Weight: 352.387

Synonyms:4-(4-fluoro-phenyl)-6-(6-fluoro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine

Chemical Property of 4-(4-fluoro-phenyl)-6-(6-fluoro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine

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Technology Process of 4-(4-fluoro-phenyl)-6-(6-fluoro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine

There total 1 articles about 4-(4-fluoro-phenyl)-6-(6-fluoro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidine (878199-72-5) + (6-fluoropyridin-3-yl)boronic acid (351019-18-6) → 4-(4-fluoro-phenyl)-6-(6-fluoro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine (896742-06-6)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 16h;

Reference yield:

4-(4-fluoro-phenyl)-6-(6-fluoro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine (896742-06-6) + piperidine-4-carboxylic acid ethyl ester hydrochloride → 5'-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid ethyl ester

Guidance literature:

With diisopropylethyl amine; In ISOPROPYLAMIDE; at 110 ℃; for 6h;

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) + 4-(4-fluoro-phenyl)-6-(6-fluoro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine (896742-06-6) → 5'-[6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-ol

Guidance literature:

In ISOPROPYLAMIDE; at 110 ℃; for 6h;

upstream raw materials:

4-chloro-6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidine

(6-fluoropyridin-3-yl)boronic acid

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