878199-72-5

Upstream product

• 833472-84-7 2,4-dichloro-6-(4-fluorophenyl)pyrimidine 
• 765-38-8 2-methyl-1-pyrrolidine 
• 833472-83-6 4,6-dichloro-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 896742-06-6 4-(4-fluoro-phenyl)-6-(6-fluoro-pyridin-3-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine 

Relevant academic research and scientific papers

A highly regioselective amination of 6-aryl-2,4-dichloropyrimidine

A highly regioselective amination of 6-aryl-2,4-dichloropyrimidine with aliphatic secondary amines and aromatic amines has been developed which strongly favors the formation of the C4-substituted product. The reactions with aliphatic amines are carried ou

SUBSTITUTED BIARYL ANALOGUES

Substituted biaryl analogues of Formula (I) are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological recep

SUBSTITUTED BIARYL PIPERAZINYL-PYRIDINE ANALOGUES

Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro,and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

BIARYL PIPERAZINYL-PYRIDINE ANALOGUES

Biaryl piperazinyl -pyri dine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands, for receptor localization studies.