8-benzyloxy-4-hydroxy-11-iodo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

Base Information

Chemical Name:8-benzyloxy-4-hydroxy-11-iodo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one
CAS No.:1620658-53-8
Molecular Formula:C₁₉H₁₇IN₂O₃
Molecular Weight:448.26
Hs Code.:

Synonyms:8-benzyloxy-4-hydroxy-11-iodo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

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Chemical Property of 8-benzyloxy-4-hydroxy-11-iodo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

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Technology Process of 8-benzyloxy-4-hydroxy-11-iodo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

There total 4 articles about 8-benzyloxy-4-hydroxy-11-iodo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1620658-49-2
7-benzyloxy-10-Iodo-3-(iodomethyl)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-one

: 1620658-53-8
8-benzyloxy-4-hydroxy-11-iodo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

Guidance literature:: With ammonia; In tetrahydrofuran; methanol; at 20 ℃; for 24h; Cooling with ice;
DOI:10.1016/j.ejmech.2014.06.063

Reference yield:

: 103781-89-1
6-benzyloxy-1H-indole-2-carboxylic acid methyl ester

: 1620658-53-8
8-benzyloxy-4-hydroxy-11-iodo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 60 h / Reflux

2: sodium hydroxide / water; ethanol / 1 h / Reflux

3: 2,6-dimethylpyridine; N-iodo-succinimide / dichloromethane / 3.5 h / -20 °C / Inert atmosphere

4: ammonia / methanol; tetrahydrofuran / 24 h / 20 °C / Cooling with ice

With 2,6-dimethylpyridine; N-iodo-succinimide; ammonia; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2014.06.063

Reference yield:

: 1620658-43-6
methyl 1-allyl-6-benzyloxy-1H-indole-2-carboxylate

: 1620658-53-8
8-benzyloxy-4-hydroxy-11-iodo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; ethanol / 1 h / Reflux

2: 2,6-dimethylpyridine; N-iodo-succinimide / dichloromethane / 3.5 h / -20 °C / Inert atmosphere

3: ammonia / methanol; tetrahydrofuran / 24 h / 20 °C / Cooling with ice

With 2,6-dimethylpyridine; N-iodo-succinimide; ammonia; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2014.06.063