3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester

Base Information

• Chemical Name: 3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester
• CAS No.: 223450-04-2
• Molecular Formula: C₄₁H₄₀N₂O₁₀S₂
• Molecular Weight: 784.908

Synonyms:3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester

Chemical Property of 3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester

Chemical Property:

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Technology Process of 3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester

There total 1 articles about 3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzyl N-(4-methylbenzenesulfonyl)carbamate (18303-10-1) + 3,5-bis[bromomethyl]benzoic acid ethyl ester (146085-71-4) → 3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester (223450-04-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 72h;

DOI:10.1055/s-1999-3385

Reference yield: 79.0%

3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester (223450-04-2) → 3,5-Bis-[(toluene-4-sulfonylamino)-methyl]-benzoic acid ethyl ester (223450-09-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In chloroform; for 6h; under 3000.2 Torr; Ambient temperature;

DOI:10.1055/s-1999-3385

Reference yield: 60.0%

3,5-bis[bromomethyl]benzoic acid ethyl ester (146085-71-4) + 3,5-Bis[N-benzyloxycarbonyl-N-(4-tolylsulfonyl)aminomethyl]benzoic acid ethyl ester (223450-04-2) → 3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.15,9]octadeca-1(17),5,7,9(18),13,15-hexaene-7,15-dicarboxylic acid diethyl ester (223450-18-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1055/s-1999-3385

upstream raw materials:

benzyl N-(4-methylbenzenesulfonyl)carbamate

3,5-bis[bromomethyl]benzoic acid ethyl ester

Downstream raw materials:

3,11-Bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaene-7,15-dicarboxylic acid diethyl ester

3,5-Bis-[(toluene-4-sulfonylamino)-methyl]-benzoic acid ethyl ester

3,7,10-tris-(toluene-4-sulfonyl)-3,7,10-triaza-1,5(1,3,5)-dibenzena-bicyclo[3.3.3]undecaphane

[15-Hydroxymethyl-3,11-bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.1^5,9]octadeca-1⁽¹⁷⁾,5,7,9⁽¹⁸⁾,13,15-hexaen-7-yl]-methanol

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