(1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(N,N-dimethylaminomethyl)-2-azabicyclo[2,2,1]heptane

Base Information

Chemical Name:(1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(N,N-dimethylaminomethyl)-2-azabicyclo[2,2,1]heptane
CAS No.:1290085-19-6
Molecular Formula:C₁₇H₂₆N₂
Molecular Weight:258.407
Hs Code.:

Synonyms:(1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(N,N-dimethylaminomethyl)-2-azabicyclo[2,2,1]heptane

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Chemical Property of (1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(N,N-dimethylaminomethyl)-2-azabicyclo[2,2,1]heptane

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Technology Process of (1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(N,N-dimethylaminomethyl)-2-azabicyclo[2,2,1]heptane

There total 5 articles about (1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(N,N-dimethylaminomethyl)-2-azabicyclo[2,2,1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1290085-12-9
(1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(aminomethyl)-2-azabicyclo[2,2,1]heptane

: 1290085-19-6
(1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(N,N-dimethylaminomethyl)-2-azabicyclo[2,2,1]heptane

Guidance literature:: With acetic acid; zinc; In 1,4-dioxane; water; at 20 ℃; for 0.5h;
DOI:10.1016/j.tetasy.2010.12.011

Reference yield:

: 1290085-08-3
(1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(azidomethyl)-2-azabicyclo[2,2,1]heptane

: 1290085-19-6
(1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(N,N-dimethylaminomethyl)-2-azabicyclo[2,2,1]heptane

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine / methanol / Reflux

2: acetic acid; zinc / 1,4-dioxane; water / 0.5 h / 20 °C

With acetic acid; triphenylphosphine; zinc; In 1,4-dioxane; methanol; water;
DOI:10.1016/j.tetasy.2010.12.011

Reference yield:

: 223505-12-2
(1R,3R,4S)-2-<(1S)-phenylethyl>-2-aza-bicyclo<2.2.1>hept-5-ene-3-carboxylic acid ethyl ester

: 1290085-19-6
(1S,3R,4R)-2-[(S)-1-phenylethyl]-3-(N,N-dimethylaminomethyl)-2-azabicyclo[2,2,1]heptane

Guidance literature:: Multi-step reaction with 5 steps

1: 5% Pd(II)/C(eggshell); hydrogen; potassium carbonate / 760.05 Torr

2: lithium aluminium tetrahydride

3: ammonia; triphenylphosphine; diethylazodicarboxylate / toluene; benzene / Cooling with ice; Inert atmosphere

4: triphenylphosphine / methanol / Reflux

5: acetic acid; zinc / 1,4-dioxane; water / 0.5 h / 20 °C

With lithium aluminium tetrahydride; 5% Pd(II)/C(eggshell); ammonia; hydrogen; potassium carbonate; acetic acid; triphenylphosphine; zinc; diethylazodicarboxylate; In 1,4-dioxane; methanol; water; toluene; benzene;
DOI:10.1016/j.tetasy.2010.12.011