Technology Process of (2S,3R,5R,6R)-6-Carbamoylmethyl-3-chloromethyl-3-methyl-4,4,7-trioxo-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester
There total 7 articles about (2S,3R,5R,6R)-6-Carbamoylmethyl-3-chloromethyl-3-methyl-4,4,7-trioxo-4λ6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium permanganate;
In
acetic acid;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 4 Angstroem molecular sieves, DBU / CH2Cl2 / 1.) -78 deg C, 2.) -78 deg C, 1.5 h; -78 deg C to 20 deg C, 1 h
2: tetrahydrofuran / 1.5 h / Ambient temperature
3: 33 percent / acetic acid, potassium azodicarboxylate / tetrahydrofuran; acetone / 48 h / Ambient temperature
4: 55 percent / 80percent aq. magnesium monoperoxyphthalate hexahydrate, benzyltrimethylammonium chloride / CHCl3 / 5 h / Ambient temperature
5: 55 percent / toluene / 4 h / Heating
6: 51 percent / CuCl2 / CH2Cl2 / 5 h / 0 - 5 °C
7: 79 percent / aq. KMnO4 / acetic acid
With
potassium permanganate; 4 A molecular sieve; potassium diazodicarboxylate; benzyltrimethylammonium chloride; magnesium monoperoxyphthalate hexahydrate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride;
In
tetrahydrofuran; dichloromethane; chloroform; acetic acid; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: tetrahydrofuran / 1.5 h / Ambient temperature
2: 33 percent / acetic acid, potassium azodicarboxylate / tetrahydrofuran; acetone / 48 h / Ambient temperature
3: 55 percent / 80percent aq. magnesium monoperoxyphthalate hexahydrate, benzyltrimethylammonium chloride / CHCl3 / 5 h / Ambient temperature
4: 55 percent / toluene / 4 h / Heating
5: 51 percent / CuCl2 / CH2Cl2 / 5 h / 0 - 5 °C
6: 79 percent / aq. KMnO4 / acetic acid
With
potassium permanganate; potassium diazodicarboxylate; benzyltrimethylammonium chloride; magnesium monoperoxyphthalate hexahydrate; acetic acid; copper dichloride;
In
tetrahydrofuran; dichloromethane; chloroform; acetic acid; acetone; toluene;
![(2S,3R,5R,6R)-6-Carbamoylmethyl-3-chloromethyl-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester](/Databaselist/images/loading.webp)
