tert-butyl 3-iodo-1-(4-(methylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate

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Chemical Name:tert-butyl 3-iodo-1-(4-(methylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate
CAS No.:1422828-04-3
Molecular Formula:C₁₇H₁₉IN₆O₂
Molecular Weight:466.281
Hs Code.:

Synonyms:tert-butyl 3-iodo-1-(4-(methylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate

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Chemical Property of tert-butyl 3-iodo-1-(4-(methylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate

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Technology Process of tert-butyl 3-iodo-1-(4-(methylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate

There total 5 articles about tert-butyl 3-iodo-1-(4-(methylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1422828-03-2
tert-butyl 1-(4-aminophenyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate

: 1422828-04-3
tert-butyl 3-iodo-1-(4-(methylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate

Guidance literature:: formaldehyd; tert-butyl 1-(4-aminophenyl)-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate; In tetrahydrofuran; water; at 30 ℃; for 4h; Inert atmosphere;

With sodium cyanoborohydride; In tetrahydrofuran; water; at 30 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; water; at 30 ℃;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1422828-04-3
tert-butyl 3-iodo-1-(4-(methylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere

2.2: -40 - 20 °C

3.1: water; iron; ammonium chloride / tetrahydrofuran; ethanol / 2 h / 50 °C / Inert atmosphere

4.1: tetrahydrofuran; water / 4 h / 30 °C / Inert atmosphere

4.2: 1 h / 30 °C

4.3: 30 °C

With water; iron; potassium carbonate; ammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1422828-02-1
tert-butyl 3-iodo-1-(4-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate

: 1422828-04-3
tert-butyl 3-iodo-1-(4-(methylamino)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; iron; ammonium chloride / tetrahydrofuran; ethanol / 2 h / 50 °C / Inert atmosphere

2.1: tetrahydrofuran; water / 4 h / 30 °C / Inert atmosphere

2.2: 1 h / 30 °C

2.3: 30 °C

With water; iron; ammonium chloride; In tetrahydrofuran; ethanol; water;