ethyl {6-[5-(4-bromophenyl)oxazol-4-yl]-5-cyano-[2-methylsulfanylpyrimidin-4-yl]sulfanyl}acetate

Base Information

Chemical Name:ethyl {6-[5-(4-bromophenyl)oxazol-4-yl]-5-cyano-[2-methylsulfanylpyrimidin-4-yl]sulfanyl}acetate
CAS No.:869578-72-3
Molecular Formula:C₁₉H₁₅BrN₄O₃S₂
Molecular Weight:491.389
Hs Code.:

Synonyms:ethyl {6-[5-(4-bromophenyl)oxazol-4-yl]-5-cyano-[2-methylsulfanylpyrimidin-4-yl]sulfanyl}acetate

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Chemical Property of ethyl {6-[5-(4-bromophenyl)oxazol-4-yl]-5-cyano-[2-methylsulfanylpyrimidin-4-yl]sulfanyl}acetate

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Technology Process of ethyl {6-[5-(4-bromophenyl)oxazol-4-yl]-5-cyano-[2-methylsulfanylpyrimidin-4-yl]sulfanyl}acetate

There total 5 articles about ethyl {6-[5-(4-bromophenyl)oxazol-4-yl]-5-cyano-[2-methylsulfanylpyrimidin-4-yl]sulfanyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 105-39-5
chloroacetic acid ethyl ester

: 869578-69-8
4-[5-(4-bromophenyl)oxazol-4-yl]-6-mercapto-2-methylsulfanylpyrimidine-5-carbonitrile

: 869578-72-3
ethyl {6-[5-(4-bromophenyl)oxazol-4-yl]-5-cyano-[2-methylsulfanylpyrimidin-4-yl]sulfanyl}acetate

Guidance literature:: With sodium acetate; In ethanol; for 3h; Heating;
DOI:10.1002/jccs.200400202

Reference yield:

: 197460-84-7
5-(4-bromophenyl)oxazole-4-carboxaldehyde

: 869578-72-3
ethyl {6-[5-(4-bromophenyl)oxazol-4-yl]-5-cyano-[2-methylsulfanylpyrimidin-4-yl]sulfanyl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / K₂CO₃ / ethanol / 24 h / Heating

2: 85 percent / NaOEt / ethanol / 5 h / Heating

3: 70 percent / POCl₃; PCl₅ / 4 h / Heating

4: 81 percent / thiourea / ethanol / 10 h / Heating

5: 68 percent / NaOAc / ethanol / 3 h / Heating

With phosphorus pentachloride; sodium ethanolate; sodium acetate; potassium carbonate; thiourea; trichlorophosphate; In ethanol;
DOI:10.1080/10426500500326792

Reference yield:

: 869578-65-4
4-[5-(4-bromophenyl)oxazol-4-yl]-6-chloro-2-methylsulfanylpyrimidine-5-carbonitrile

: 869578-72-3
ethyl {6-[5-(4-bromophenyl)oxazol-4-yl]-5-cyano-[2-methylsulfanylpyrimidin-4-yl]sulfanyl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / thiourea / ethanol / 10 h / Heating

2: 68 percent / NaOAc / ethanol / 3 h / Heating

With sodium acetate; thiourea; In ethanol;
DOI:10.1080/10426500500326792