2-[(4-trifluoromethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 2-[(4-trifluoromethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1057280-60-0
• Molecular Formula: C₁₆H₁₄F₃NO
• Molecular Weight: 293.288
• Mol file: 1057280-60-0.mol

Synonyms:2-[(4-trifluoromethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 2-[(4-trifluoromethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[(4-trifluoromethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about 2-[(4-trifluoromethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3,4-tetrahydroisoquinoline (91-21-4) + 1-iodo-4-(trifluoromethoxy)benzene (103962-05-6) → 2-[(4-trifluoromethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline (1057280-60-0)

Guidance literature:

With potassium phosphate; copper(l) iodide; In ethylene glycol; isopropyl alcohol; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201600050

Reference yield: 89.0%

2-[(4-trifluoromethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline (1057280-60-0) + N,N-diethyl-α,α-difluoro-α-(trimethylsilyl)acetamide → N,N-diethyl-2,2-difluoro-2-(2-(4-(trifluoromethoxy)phenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetamide

Guidance literature:

With cesium fluoride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01997

Reference yield: 80.0%

2-[(4-trifluoromethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline (1057280-60-0) + potassium phenethylpentafluorosilicate → N-(4-trifluromethoxyphenyl)-1-(phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:

With tetrabutyl ammonium fluoride; water; copper(II) bis(trifluoromethanesulfonate); potassium hydrogencarbonate; diethylamine; In tetrachloromethane; at 80 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01124

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

1-iodo-4-(trifluoromethoxy)benzene