(2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine

Base Information

Chemical Name:(2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine
CAS No.:908848-04-4
Molecular Formula:C₃₇H₇₁NO₄SSi₂
Molecular Weight:682.212
Hs Code.:

Synonyms:(2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine

Suppliers and Price of (2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine

There total 2 articles about (2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₇₅NO₇S₂Si₂

: 908848-04-4
(2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 40h;
DOI:10.1016/j.bmc.2007.10.008

Reference yield:

: 205371-64-8
N-[(1S,2S,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-hydroxy-heptadecyl]-4-methyl-benzenesulfonamide

: 908848-04-4
(2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 18 h / 0 - 4 °C

2: sodium hydride / tetrahydrofuran / 40 h / 0 - 20 °C

With pyridine; sodium hydride; In tetrahydrofuran;

Reference yield:

: 908848-04-4
(2S,3R,4S)-3-(tert-butyldimethylsilyloxy)-2-[(tert-butyldimethylsilyloxy)methyl]-4-tetradecyl-1-(p-toluenesulfonyl)azetidine

: (2S,3R,4S)-2-[(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyloxy)methyl]-4-tetradecyl-1-hexacosanoylazetidin-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: naphthalene; sodium / 1,2-dimethoxyethane / 4.5 h / -78 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 62 h / 20 °C

3: trifluorormethanesulfonic acid; water / tetrahydrofuran / 3 h / 0 - 20 °C

4: 4 A molecular sieve; tin chloride; silver perchlorate / tetrahydrofuran / 5.5 h / -20 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / 20 °C

With naphthalene; trifluorormethanesulfonic acid; 4 A molecular sieve; tin chloride; tetrabutyl ammonium fluoride; water; silver perchlorate; sodium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;